ArticleHuman heredity2008
Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.
Article in Human heredity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish.BMJ open diabetes research & care · 2020Article
- Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish.Obesity science & practice · 2018Article
- Article
- Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.PloS one · 2012Article
- Persistent Staphylococcus aureus colonization is not a strongly heritable trait in Amish families.PloS one · 2011Article
- Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.Clinical and translational science · 2011Article
- Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications.American journal of human genetics · 2010Article
- PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.BMC medical genetics · 2010Article
- Extent and distribution of linkage disequilibrium in the Old Order Amish.Genetic epidemiology · 2010Article
- Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).The American journal of cardiology · 2009Article
- A genome-wide scan in an Amish pedigree with parkinsonism.Annals of human genetics · 2008Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesUsing Y chromosome short tandem repeat (YSTR) genotypes, (1) evaluate the accuracy and completeness of the Lancaster County Old Order Amish (OOA) genealogical records and (2) estimate YSTR mutation rates.
methodsNine YSTR markers were genotyped in 739 Old Order Amish males who participated in several ongoing genetic studies of complex traits and could be connected into one of 28 all-male lineage pedigrees constructed using the Anabaptist Genealogy Database and the query software Ped-Hunter. A putative founder YSTR haplotype was constructed for each pedigree, and observed and inferred father-son transmissions were used to estimate YSTR mutation rates.
resultsWe inferred 27 distinct founder Y chromosome haplotypes in the 28 male lineages, which encompassed 27 surnames accounting for 98% of Lancaster OOA households. Nearly all deviations from founder haplotypes were consistent with mutation events rather than errors. The estimated marker-specific mutation rates ranged from 0 to 1.09% (average 0.33% using up to 283 observed meioses only and 0.28% using up to 1,232 observed and inferred meioses combined).
conclusionsThese data confirm the accuracy and completeness of the male lineage portion of the Anabaptist Genealogy Database and contribute mutation rate estimates for several commonly used Y chromosome STR markers.
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