ReviewPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2007
Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response?
Review in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.European journal of pain (London, England) · 2011Trial
- Opioid dependence in patients with pain in chronic pancreatitis an emerging problem.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- The Mechanism of HDAC2 Inhibitors on Chronic Pancreatitis Pain.Journal of neurological surgery reports · 2025Article
- Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview.Frontiers in physiology · 2025Review
- Pain in chronic pancreatitis: What can we do today?World journal of methodology · 2024Review
- Percutaneous Fluoroscopic-Guided Celiac Plexus Approach: Results in a Pig Cadaveric Model.Animals : an open access journal from MDPI · 2024Article
- Neuropancreatology: The Nervous System and Pain Management in Pancreatic Diseases.Life (Basel, Switzerland) · 2024Review
- Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.Neuroscience bulletin · 2022Article
- Transcranial Direct Current Stimulation Alleviates the Chronic Pain of Osteoarthritis by Modulating NMDA Receptors in Midbrain Periaqueductal Gray in Rats.Journal of pain research · 2022Article
- Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats.Molecular brain · 2019Article
- Effects of Transcranial Direct Current Stimulation on Knee Osteoarthritis Pain in Elderly Subjects With Defective Endogenous Pain-Inhibitory Systems: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2018Article
- Effects of Transcranial Direct Current Stimulation, Transcranial Pulsed Current Stimulation, and Their Combination on Brain Oscillations in Patients with Chronic Visceral Pain: A Pilot Crossover Randomized Controlled Study.Frontiers in neurology · 2017Article
- Sensory nerves and pancreatitis.Gland surgery · 2014Review
- Pancreatic pain.Wiener medizinische Wochenschrift (1946) · 2014Review
- Pain in chronic pancreatitis: managing beyond the pancreatic duct.World journal of gastroenterology · 2013Review
- The pain of chronic pancreatitis: a persistent clinical challenge.British journal of pain · 2013Article
- Nerve-cancer interactions in the stromal biology of pancreatic cancer.Frontiers in physiology · 2012Article
- Pain mechanisms in chronic pancreatitis: of a master and his fire.Langenbeck's archives of surgery · 2011Review
- Brain stimulation for the treatment of pain: A review of costs, clinical effects, and mechanisms of treatment for three different central neuromodulatory approaches.Journal of pain management · 2009Article
- Spinal Cord Stimulation for Intractable Visceral Pain due to Chronic Pancreatitis.Journal of Korean Neurosurgical Society · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pain in chronic pancreatitis is frequently refractory to medical and even surgical treatment. This refractoriness leads us to believe that a pancreas-independent, brain-mediated mechanism must be responsible. If so, several scenarios are worth considering. First, chronic pain could be the consequence of undesirable neuroplastic changes, by which pathology becomes established and causes disability. Alternatively, pain may be linked to the salutogenic (from salutogenesis, the Latin word for health and well-being) central nervous system response (we defined 'salutogenic response' as the specific modulation of the immune system induced by brain activity changes) to promote healing of the injured viscera. If so, chronic pain could index the ongoing nervous system attempt to promote healing. In this review, we discuss (1) the mechanisms of pain in chronic pancreatitis; (2) potential brain-related salutogenic mechanisms, and (3) the potential relationship of these two factors to the disease status. Furthermore, we consider these aspects in light of a new approach to treat visceral pain: transcranial magnetic stimulation, a noninvasive method of brain stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.