ArticleProceedings of the National Academy of Sciences of the United States of America2007
Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 135 citations in OpenAlex.
- Whole-transcriptome insights into light-responsive non-coding RNA networks regulating circadian clock and DNA repair in zebrafish.Functional & integrative genomics · 2026Article
- Heat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells.Scientific reports · 2024Article
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- Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway.BMC plant biology · 2024Article
- Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.International journal of molecular sciences · 2023Review
- Seasonal Changes in Photoperiod: Effects on Growth and Redox Signaling Patterns in Atlantic Salmon Postsmolts.Antioxidants (Basel, Switzerland) · 2023Article
- Immunity, Infection, and the Zebrafish Clock.Infection and immunity · 2022Review
- Circadian Rhythm Regulates Reactive Oxygen Species Production and Inhibits Al-Induced Programmed Cell Death in Peanut.Life (Basel, Switzerland) · 2022Article
- Toxicity of gold nanorods on Ceriodaphnia dubia and Danio rerio after sub-lethal exposure and recovery.Environmental science and pollution research international · 2021Article
- Adaptation and convergence in circadian-related genes in Iberian freshwater fish.BMC ecology and evolution · 2021Article
- Protein kinase A controls yeast growth in visible light.BMC biology · 2020Article
- Article
- Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating.Annual review of physiology · 2020Review
- Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates.Current genomics · 2019Review
- Evolution Shapes the Gene Expression Response to Oxidative Stress.International journal of molecular sciences · 2019Review
- Circadian Clocks in Fish-What Have We Learned so far?Biology · 2019Review
- The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish.Scientific reports · 2019Article
- Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates.Scientific reports · 2018Article
- Cellular Timekeeping: It's Redox o'Clock.Cold Spring Harbor perspectives in biology · 2018Review
- Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations.Antioxidants & redox signaling · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light is the key entraining stimulus for the circadian clock, but several features of the signaling pathways that convert the photic signal to clock entrainment remain to be deciphered. Here, we show that light induces the production of hydrogen peroxide (H(2)O(2)) that acts as the second messenger coupling photoreception to the zebrafish circadian clock. Treatment of light-responsive Z3 cells with H(2)O(2) triggers the induction of zCry1a and zPer2 genes and the subsequent circadian oscillation of zPer1. Remarkably, the induction kinetics and oscillation profile in response to H(2)O(2) are identical to those initiated by light. Catalase (Cat), an antioxidant enzyme degrading H(2)O(2), shows an oscillating pattern of expression and activity, antiphasic to zCry1a and zPer2. Interestingly, overexpression of zCAT results in a reduced light-dependent zCry1a and zPer2 gene induction. In contrast, inhibition of zCAT function enhances light-mediated inducibility of these clock genes. These findings implicate the enzymatic function of zCAT enzyme in the negative regulation of light-dependent clock gene transcriptional activation. Our findings provide an attractive link between the regulation of the cellular reduction/oxidation (redox) state and the photic signaling pathways implicated in circadian control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.