ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2007
Pregnancy increases baroreflex-independent GABAergic inhibition of the RVLM in rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Subregional differences in GABAThe Journal of comparative neurology · 2020Article
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.Journal of hypertension · 2019Review
- Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women.American journal of physiology. Heart and circulatory physiology · 2017Article
- Acute hypoxia activates neuroendocrine, but not presympathetic, neurons in the paraventricular nucleus of the hypothalamus: differential role of nitric oxide.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Angiotensin II system in the nucleus tractus solitarii contributes to autonomic dysreflexia in rats with spinal cord injury.PloS one · 2017Article
- Relaxin increases sympathetic nerve activity and activates spinally projecting neurons in the paraventricular nucleus of nonpregnant, but not pregnant, rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Disinhibition of RVLM neural circuits and regulation of sympathetic nerve discharge at peak hyperthermia.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Is visceral sympathoexcitation to heat stress dependent on activation of ionotropic excitatory amino acid receptors in the rostral ventrolateral medulla?American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Differential activation of adrenal, renal, and lumbar sympathetic nerves following stimulation of the rostral ventrolateral medulla of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii.Respiratory physiology & neurobiology · 2010Article
- Pregnancy and the endocrine regulation of the baroreceptor reflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
- Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus.Physiology & behavior · 2009Article
- Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats.Brain research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During baroreceptor unloading, sympathoexcitation is attenuated in near-term pregnant compared with nonpregnant rats. Alterations in balance among different excitatory and inhibitory inputs within central autonomic pathways likely contribute to changes in regulation of sympathetic outflow in pregnancy. Both baroreflex-dependent and baroreflex-independent GABAergic inputs inhibit sympathoexcitatory neurons within rostral ventrolateral medulla (RVLM). The present experiments tested the hypothesis that influence of baroreflex-independent GABAergic inhibition of RVLM is greater in pregnant compared with nonpregnant rats. Afferent baroreceptor inputs were eliminated by bilateral sinoaortic denervation in inactin-anesthetized rats. In pregnant compared with nonpregnant rats, baseline mean arterial pressure (MAP) was lower (pregnant = 75 +/- 6 mmHg, nonpregnant = 115 +/- 7 mmHg) and heart rate was higher (pregnant = 381 +/- 10 beats/min, nonpregnant = 308 +/- 10 beats/min). Pressor and sympathoexcitatory [renal sympathetic nerve activity, (RSNA)] responses due to bilateral GABA(A) receptor blockade (bicuculline, 4 mM, 100 nl) of the RVLM were greater in pregnant rats (delta MAP: pregnant = 101 +/- 4 mmHg, nonpregnant = 80 +/- 6 mmHg; delta RSNA: pregnant = 182 +/- 23% control, nonpregnant = 133 +/- 10% control). Unexpected transient sympathoexcitatory effects of angiotensin AT(1) receptor blockade in the RVLM were greater in pregnant rats. Although excitatory responses to bicuculline were attenuated by prior RVLM AT1 receptor blockade in both groups, pressor responses to disinhibition of the RVLM remained augmented in pregnant rats. Increased influence of baroreflex-independent GABAergic inhibition in RVLM could contribute to suppressed sympathoexcitation during withdrawal of arterial baroreceptor input in pregnant animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.