ArticleJournal of virology2007
A novel virus detected in papillomas and carcinomas of the endangered western barred bandicoot (Perameles bougainville) exhibits genomic features of both the Papillomaviridae and Polyomaviridae.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 80 citations in OpenAlex.
- Immune Responses of Dendritic Cells to Zoonotic DNA and RNA Viruses.Veterinary sciences · 2025Review
- Widespread Horizontal Gene Transfer Among Animal Viruses.bioRxiv : the preprint server for biology · 2024Article
- Structural similarity of human papillomavirus E4 and polyomaviral VP4 exhibited by genomic analysis of the common kestrel (Falco tinnunculus) polyomavirus.Veterinary research communications · 2024Article
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- Divergent hepaciviruses, delta-like viruses, and a chu-like virus in Australian marsupial carnivores (dasyurids).Virus evolution · 2023Article
- Interpreting and de-noising genetically engineered barcodes in a DNA virus.PLoS computational biology · 2022Article
- Review
- Identification of a novel polyomavirus from a marsupial host.Virus evolution · 2022Article
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- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Adintoviruses: a proposed animal-tropic family of midsize eukaryotic linear dsDNA (MELD) viruses.Virus evolution · 2021Article
- Meta-transcriptomic identification of Trypanosoma spp. in native wildlife species from Australia.Parasites & vectors · 2020Article
- Papillomaviruses infecting cetaceans exhibit signs of genome adaptation following a recombination event.Virus evolution · 2020Article
- Genome Plasticity in Papillomaviruses and De Novo Emergence of E5 Oncogenes.Genome biology and evolution · 2019Article
- Cancer in wildlife: patterns of emergence.Nature reviews. Cancer · 2018Review
- Transcriptome sequencing of the long-nosed bandicoot (Perameles nasuta) reveals conservation and innovation of immune genes in the marsupial order Peramelemorphia.Immunogenetics · 2018Article
- Fish polyomaviruses belong to two distinct evolutionary lineages.The Journal of general virology · 2018Article
- Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (Isoodon macrourus).Veterinary sciences · 2017Article
- A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene.PLoS pathogens · 2016Article
- The Ancient Evolutionary History of Polyomaviruses.PLoS pathogens · 2016Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conservation efforts to prevent the extinction of the endangered western barred bandicoot (Perameles bougainville) are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild populations. In this study, we detected a novel virus, designated the bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1), in lesional tissue from affected western barred bandicoots using multiply primed rolling-circle amplification and PCR with the cutaneotropic papillomavirus primer pairs FAP59/FAP64 and AR-L1F8/AR-L1R9. Sequencing of the BPCV1 genome revealed a novel prototype virus exhibiting genomic properties of both the Papillomaviridae and the Polyomaviridae. Papillomaviral properties included a large genome size ( approximately 7.3 kb) and the presence of open reading frames (ORFs) encoding canonical L1 and L2 structural proteins. The genomic organization in which structural and nonstructural proteins were encoded on different strands of the double-stranded genome and the presence of ORFs encoding the nonstructural proteins large T and small t antigens were, on the other hand, typical polyomaviral features. BPCV1 may represent the first member of a novel virus family, descended from a common ancestor of the papillomaviruses and polyomaviruses recognized today. Alternatively, it may represent the product of ancient recombination between members of these two virus families. The discovery of this virus could have implications for the current taxonomic classification of Papillomaviridae and Polyomaviridae and can provide further insight into the evolution of these ancient virus families.
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Registered trials
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