Evidence map›Paper›PMID 17897974›Full record

ArticleTobacco control2007

Trends in nicotine yield in smoke and its relationship with design characteristics among popular US cigarette brands, 1997-2005.

Gregory N Connolly, Hillel R Alpert, Geoffrey Ferris Wayne, Howard Koh

Open access · bronzeAbstract read
In one paragraph

Article in Tobacco control, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 68 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Electronic Cigarette Nicotine Flux, Nicotine Yield, and Particulate Matter Emissions: Impact of Device and Liquid Heterogeneity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  6. Article
  7. Nicotine Content in Swedish-Type Snus Sold in Norway From 2005 to 2020.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Pharmacokinetic Profile of Spectrum Reduced Nicotine Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Electronic cigarette effectiveness and abuse liability: predicting and regulating nicotine flux.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Article
  19. Dopamine function in cigarette smokers: an [¹⁸F]-DOPA PET study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gregory N ConnollyHarvard School of Public Health, Division of Public Health Practice, Landmark Building, 677 Huntington Avenue, Boston, MA 02115, USA. gconnoll@hsph.harvard.edu
Hillel R Alpert
Geoffrey Ferris Wayne
Howard Koh
Harvard University · US

Funding

Design and Characterization on CigarettesR01CA087477 · NCI · NORTHEASTERN UNIVERSITY · PI CONNOLLY, GREGORY NILES · 2000 to 2015
$5.2M
NCI NIH HHS R01 CA087477NCI NIH HHS R01 CA87477-07
6 · The paper itself

Abstract

objectivesTo determine whether nicotine yields in the smoke of cigarettes would show an overall increase over time or an increasing trend limited to any particular market category (eg, full flavour vs light, medium (mild) or ultralight; mentholated vs non-mentholated), manufacturer, or brand family or brand style, and whether nicotine yields in smoke would be associated with measurable trends in cigarette design.

methodsMachine-based measures of nicotine yield in smoke and measures of cigarette design features related to nicotine delivery (ventilation, nicotine content in the tobacco rod and number of puffs), as well as market category descriptors, were obtained from annual reports filed with the Massachusetts Department of Public by tobacco manufacturers for 1997-2005. Trends in nicotine yield and its relationship with design features and market parameters were analysed with multilevel mixed-effects regression modelling procedures.

resultsA statistically significant trend was confirmed in increased nicotine yield, of 0.019 (1.1%) mg/cig/year over the period 1997-2005 and 0.029 (1.6%) mg/cig/year over the period 1998-2005. The increasing trend was observed in all major market categories (mentholated vs non-mentholated, and full flavour vs light, medium (mild) or ultralight). Nicotine yield in smoke was positively associated with nicotine concentration in the tobacco and number of puffs per cigarette, both of which showed increasing trends during the study period.

conclusionsThis study confirms increased machine-measured levels of nicotine, the addictive agent in cigarettes, in smoke, to be a result of increased nicotine in the tobacco rod and other design modifications.

Indexed as

HumansNicotineSmokeSmokingTobacco IndustryUnited StatesNicotineSmoke

Identifiers

PMID17897974
PMCPMC2598548
OpenAlexW2146157387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.