ArticleBMC evolutionary biology2007
Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
- Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution.Nature communications · 2025Article
- Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma.PloS one · 2023Article
- Epipolythiodioxopiperazine-Based Natural Products: Building Blocks, Biosynthesis and Biological Activities.Chembiochem : a European journal of chemical biology · 2022Review
- A Secondary Metabolism Pathway Involved in the Production of a Putative Toxin Is Expressed at Early Stage ofFrontiers in plant science · 2022Article
- Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways.Microbiology spectrum · 2021Article
- Regulation of Secondary Metabolism in theInternational journal of molecular sciences · 2020Review
- The Architecture of Metabolism Maximizes Biosynthetic Diversity in the Largest Class of Fungi.Molecular biology and evolution · 2020Article
- Identification and distribution of gene clusters required for synthesis of sphingolipid metabolism inhibitors in diverse species of the filamentous fungus Fusarium.BMC genomics · 2020Article
- Biosynthetic gene clusters and the evolution of fungal chemodiversity.Natural product reports · 2020Article
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
- Enlightening Gliotoxin Biological System in Agriculturally RelevantFrontiers in microbiology · 2020Article
- Interaction of a Novel Zn2Cys6 Transcription Factor DcGliZ with Promoters in the Gliotoxin Biosynthetic Gene Cluster of the Deep-Sea-Derived FungusBiomolecules · 2019Article
- Complex Evolutionary Origins of Specialized Metabolite Gene Cluster Diversity among the Plant Pathogenic Fungi of the Fusarium graminearum Species Complex.Genome biology and evolution · 2019Article
- The birth, evolution and death of metabolic gene clusters in fungi.Nature reviews. Microbiology · 2018Review
- Review
- Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei.Applied microbiology and biotechnology · 2018Review
- Genomic characterization of Trichoderma atrobrunneum (T. harzianum species complex) ITEM 908: insight into the genetic endowment of a multi-target biocontrol strain.BMC genomics · 2018Article
- Production of the Invasive Aspergillosis Biomarker Bis(methylthio)gliotoxin Within the GenusFrontiers in microbiology · 2018Article
- Locus-aware decomposition of gene trees with respect to polytomous species trees.Algorithms for molecular biology : AMB · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenes responsible for biosynthesis of fungal secondary metabolites are usually tightly clustered in the genome and co-regulated with metabolite production. Epipolythiodioxopiperazines (ETPs) are a class of secondary metabolite toxins produced by disparate ascomycete fungi and implicated in several animal and plant diseases. Gene clusters responsible for their production have previously been defined in only two fungi. Fungal genome sequence data have been surveyed for the presence of putative ETP clusters and cluster data have been generated from several fungal taxa where genome sequences are not available. Phylogenetic analysis of cluster genes has been used to investigate the assembly and heredity of these gene clusters.
resultsPutative ETP gene clusters are present in 14 ascomycete taxa, but absent in numerous other ascomycetes examined. These clusters are discontinuously distributed in ascomycete lineages. Gene content is not absolutely fixed, however, common genes are identified and phylogenies of six of these are separately inferred. In each phylogeny almost all cluster genes form monophyletic clades with non-cluster fungal paralogues being the nearest outgroups. This relatedness of cluster genes suggests that a progenitor ETP gene cluster assembled within an ancestral taxon. Within each of the cluster clades, the cluster genes group together in consistent subclades, however, these relationships do not always reflect the phylogeny of ascomycetes. Micro-synteny of several of the genes within the clusters provides further support for these subclades.
conclusionETP gene clusters appear to have a single origin and have been inherited relatively intact rather than assembling independently in the different ascomycete lineages. This progenitor cluster has given rise to a small number of distinct phylogenetic classes of clusters that are represented in a discontinuous pattern throughout ascomycetes. The disjunct heredity of these clusters is discussed with consideration to multiple instances of independent cluster loss and lateral transfer of gene clusters between lineages.
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