Trial reportCardiovascular ultrasound2007
Exercise training does not improve myocardial diastolic tissue velocities in Type 2 diabetes.
Trial report in Cardiovascular ultrasound, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01053091 (Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise-based Rehabilitation on Circulatory Functions in Patients With Diastolic Heart Failure
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of the effects of different exercise modes on cardiac function and peak oxygen uptake in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Pooled it
- Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Lack of effects of pioglitazone on cardiac function in patients with type 2 diabetes and evidence of left ventricular diastolic dysfunction: a tissue doppler imaging study.Cardiovascular diabetology · 2010Trial
- Walking Improves Cardiac Function: A Trial on the Effects of Walking on Left Ventricular Function in Type 2 Diabetes Patients.Journal of cardiovascular development and disease · 2026Article
- Effects of exercise on cardiac structure and function in patients with type 2 diabetes: a narrative review of prospective imaging studies.The international journal of cardiovascular imaging · 2025Review
- Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?PeerJ · 2021Article
- Effects of recreational football on women's fitness and health: adaptations and mechanisms.European journal of applied physiology · 2018Review
- Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome.Heart failure reviews · 2012Review
- Recruitment of patients with type 2 diabetes for target group specific exercise programs at an Outpatient Department of a Medical University: A factor analysis.Wiener klinische Wochenschrift · 2011Article
- Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction.Cardiovascular diabetology · 2011Article
- Predictors of diastolic dysfunction among minority patients with newly diagnosed type 2 diabetes.Diabetes research and clinical practice · 2010Article
- Diastolic dysfunction in exercise and its role for exercise capacity.Heart failure reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial diastolic tissue velocities are reduced already in newly onset Type 2 diabetes mellitus (T2D). Poor disease control may lead to left ventricular (LV) systolic dysfunction and heart failure. The aim of this study was to assess the effects of exercise training on myocardial diastolic function in T2D patients without ischemic heart disease.
methods48 men (52.3 +/- 5.6 yrs) with T2D were randomized to supervised training four times a week and standard therapy (E), or standard treatment alone (C) for 12 months. Glycated hemoglobin (HbA1c), oxygen consumption (VO2max), and muscle strength (Sit-up) were measured. Tissue Doppler Imaging (TDI) was used to determine the average maximal mitral annular early (Ea) and late (Aa) diastolic as well as systolic (Sa) velocities, systolic strain (epsilon) and strain rate (epsilon) from the septum, and an estimation of left ventricular end diastolic pressure (E/Ea).
resultsExercise capacity (VO2max, E 32.0 to 34.7 vs. C 32.6 to 31.5 ml/kg/min, p = .001), muscle strength (E 12.7 to 18.3 times vs. C 14.6 to 14.7 times, p < .001), and HbA1c (E 8.2 to 7.5% vs. C 8.0 to 8.4%, p = .006) improved significantly in the exercise group compared to the controls (ANOVA). Systolic blood pressure decreased in the E group (E 144 to 138 mmHg vs. C 146 to 144 mmHg, p = .04). Contrary to risk factor changes diastolic long axis relaxation did not improve significantly, early diastolic velocity Ea from 8.1 to 7.9 cm/s for the E group vs. C 7.4 to 7.8 cm/s (p = .85, ANOVA). Likewise, after 12 months the mitral annular systolic velocity, systolic strain and strain rate, as well as E/Ea were unchanged.
conclusionExercise training improves endurance and muscle fitness in T2D, resulting in better glycemic control and reduced blood pressure. However, myocardial diastolic tissue velocities did not change significantly. Our data suggest that a much longer exercise intervention may be needed in order to reverse diastolic impairment in diabetics, if at all possible.
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