ArticleJournal of inflammation (London, England)2007
Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice.
Article in Journal of inflammation (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Ferroptosis-related stress during aging and its relevance to disease.GeroScience · 2026Review
- Plasma EAAT2 and GABA as candidate biomarkers in males with autism spectrum disorder: an exploratory case-control study with ROC analysis.Scientific reports · 2026Article
- The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages.Cell insight · 2025Article
- The Role of SLC7A11 in Cancer: Friend or Foe?Cancers · 2022Review
- P2X7 Receptor Augments LPS-Induced Nitrosative Stress by Regulating Nrf2 and GSH Levels in the Mouse Hippocampus.Antioxidants (Basel, Switzerland) · 2022Article
- Ferroptosis: A New Strategy for Cancer Therapy.Frontiers in oncology · 2022Review
- Review
- Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.Free radical research · 2020Article
- Decreased epileptogenesis in mice lacking the System xEpilepsia open · 2019Article
- NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Development of a primary microglia screening assay and its use to characterize inhibition of system xBiochemistry and biophysics reports · 2017Article
- Genomic analysis of xCT-mediated regulatory network: Identification of novel targets against AIDS-associated lymphoma.Oncotarget · 2015Article
- Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function.The Journal of biological chemistry · 2015Article
- xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases.Frontiers in microbiology · 2015Article
- Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.Molecular and cellular biology · 2014Article
- Change of cystine/glutamate antiporter expression in ethanol-dependent rats.Frontiers in neuroscience · 2014Article
- The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Antioxidants & redox signaling · 2013Review
- Neurotransmitter signaling in the pathophysiology of microglia.Frontiers in cellular neuroscience · 2013Article
- The role of central 5-HT(2C) and NMDA receptors on LPS-induced feeding behavior in chickens.The journal of physiological sciences : JPS · 2012Article
- Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling.Pharmacological reviews · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCystine/glutamate transporter, system xc-, contributes to the maintenance of intracellular glutathione levels and the redox balance in the extracellular space. The main component of the transporter, xCT, is known to be strongly induced by various stimuli like oxidative stress in mammalian cultured cells. We examined the expression of xCT mRNA in vivo in the experimental endotoxemia.
methodsNorthern blot analysis and in situ hybridization were used to investigate the expression of xCT mRNA in the tissues of the mice exposed to bacterial lipopolysaccharide (LPS).
resultsNorthern blot analysis revealed that xCT mRNA was constitutively expressed in the brain, thymus, and spleen, and that the expression of xCT mRNA was strongly up-regulated in thymus and spleen by the administration of a sublethal dose of LPS. In addition to brain, thymus, and spleen, xCT mRNA was detected also in the bronchiolar epithelium of the lung by the administration of the lethal dose of LPS.
conclusionxCT is induced in some specific tissues by the administration of LPS. The results suggest that cystine/glutamate transporter plays an important role under the inflammatory conditions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.