ArticlePloS one2007
Can ID repetitive elements serve as cis-acting dendritic targeting elements? An in vivo study.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Reading the SINEs - functionality in noncoding RNA 'cheap genes'.RNA biology · 2026Review
- A Nanotube Injector for Cytoplasmic Transfer and Enhanced Mitochondrial Function.Small science · 2026Article
- BC1 RNA motifs required for dendritic transport in vivo.Scientific reports · 2016Article
- Non-coding functions of alternative pre-mRNA splicing in development.Seminars in cell & developmental biology · 2015Review
- Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.The Journal of cell biology · 2014Article
- Alternative pre-mRNA splicing in neurons: growing up and extending its reach.Trends in genetics : TIG · 2013Review
- Translational control at the synapse: role of RNA regulators.Trends in biochemical sciences · 2013Review
- Control of cytoplasmic mRNA localization.Cellular and molecular life sciences : CMLS · 2012Review
- Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.The Journal of cell biology · 2011Article
- Cytoplasmic intron sequence-retaining transcripts can be dendritically targeted via ID element retrotransposons.Neuron · 2011Article
- Retroelements and their impact on genome evolution and functioning.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic localization of mRNA/RNA involves interaction of cis-elements and trans-factors. Small, non-protein coding dendritic BC1 RNA is thought to regulate translation in dendritic microdomains. Following microinjections into cultured cells, BC1 RNA fused to larger mRNAs appeared to impart transport competence to these chimeras, and its 5' ID region was proposed as the cis-acting dendritic targeting element. As these ID elements move around rodent genomes and, if transcribed, form a long RNA stem-loop, they might, thereby, lead to new localizations for targeted gene products. To test their targeting ability in vivo we created transgenic mice expressing various ID elements fused to the 3' UTR of reporter mRNA for Enhanced Green Fluorescent Protein. In vivo, neither ID elements nor the BC1 RNA coding region were capable of transporting EGFP RNA to dendrites, although the 3' UTR of alpha-CaMKII mRNA, an established cis-acting element did produce positive results. Other mRNAs containing naturally inserted ID elements are also not found in neuronal dendrites. We conclude that the 5' ID domain from BC1 RNA is not a sufficient dendritic targeting element for mRNAs in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.