ArticlePloS one2007
Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinks.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed.
- Rising from the fragments: a multi-factorial regulatory framework of DNA damage response in Deinococcus radiodurans.Extremophiles : life under extreme conditions · 2026Review
- Predicting the metalloproteome of Deinococcus indicus DR1 through integrative structure and function annotation.Biodegradation · 2026Article
- Physiological Changes and Transposition of Insertion Sequences in theInternational journal of molecular sciences · 2026Article
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- Radiation-response inFEMS microbes · 2026Article
- The -10 region adjacent to open reading frames is a common expression pattern inLife science alliance · 2025Article
- Computational-Experimental Identification of Palindromic Motifs Bound by Bacterial XRE Family Transcriptional Regulators.Life (Basel, Switzerland) · 2025Article
- Irrigation water quality shapes soil microbiomes: a 16 S rRNA-based biogeographic study in arid ecosystems.Scientific reports · 2025Article
- Bacterial PprI-DdrO system evolved from ImmA-ImmR system in the prophage.Protein science : a publication of the Protein Society · 2025Article
- The ternary complex of MnProceedings of the National Academy of Sciences of the United States of America · 2024Article
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- The Transposition of Insertion Sequences in Sigma-Factor- and LysR-Deficient Mutants ofMicroorganisms · 2024Article
- Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences.Frontiers in microbiology · 2024Review
- DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm.Frontiers in microbiology · 2024Article
- A Novel Glycoside Hydrolase DogH Utilizing Soluble Starch to Maltose Improve Osmotic Tolerance inInternational journal of molecular sciences · 2023Article
- Complete genome sequence ofFrontiers in bioengineering and biotechnology · 2023Article
- Complementary Roles of Two DNA Protection Proteins fromInternational journal of molecular sciences · 2022Article
- iTRAQ-based proteomic analysis of Deinococcus radiodurans in response toBMC microbiology · 2022Article
- Deinococcus taeanensis sp. nov., a Radiation-Resistant Bacterium Isolated from a Coastal Dune.Current microbiology · 2022Article
- Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions.Biology direct · 2022Article
54 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors.
Funding
Abstract
Bacteria of the genus Deinococcus are extremely resistant to ionizing radiation (IR), ultraviolet light (UV) and desiccation. The mesophile Deinococcus radiodurans was the first member of this group whose genome was completely sequenced. Analysis of the genome sequence of D. radiodurans, however, failed to identify unique DNA repair systems. To further delineate the genes underlying the resistance phenotypes, we report the whole-genome sequence of a second Deinococcus species, the thermophile Deinococcus geothermalis, which at its optimal growth temperature is as resistant to IR, UV and desiccation as D. radiodurans, and a comparative analysis of the two Deinococcus genomes. Many D. radiodurans genes previously implicated in resistance, but for which no sensitive phenotype was observed upon disruption, are absent in D. geothermalis. In contrast, most D. radiodurans genes whose mutants displayed a radiation-sensitive phenotype in D. radiodurans are conserved in D. geothermalis. Supporting the existence of a Deinococcus radiation response regulon, a common palindromic DNA motif was identified in a conserved set of genes associated with resistance, and a dedicated transcriptional regulator was predicted. We present the case that these two species evolved essentially the same diverse set of gene families, and that the extreme stress-resistance phenotypes of the Deinococcus lineage emerged progressively by amassing cell-cleaning systems from different sources, but not by acquisition of novel DNA repair systems. Our reconstruction of the genomic evolution of the Deinococcus-Thermus phylum indicates that the corresponding set of enzymes proliferated mainly in the common ancestor of Deinococcus. Results of the comparative analysis weaken the arguments for a role of higher-order chromosome alignment structures in resistance; more clearly define and substantially revise downward the number of uncharacterized genes that might participate in DNA repair and contribute to resistance; and strengthen the case for a role in survival of systems involved in manganese and iron homeostasis.
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