Trial reportPloS one2007
Lactate, fructose and glucose oxidation profiles in sports drinks and the effect on exercise performance.
Trial report in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Design-Driven Gel-Based Delivery Systems for Bioactives in Sports Nutrition.Gels (Basel, Switzerland) · 2026Review
- Molecular vehicles for therapeutic delivery of lactate in exercise and medicine.Sports medicine and health science · 2026Review
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- The Dual Role of Lactate in the Exercising Brain: Fueling Energy and Signaling Fatigue.Advances in neurobiology · 2025Review
- Aging delays the suppression of lipolysis and fatty acid oxidation in the postprandial period.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of Oral Lactate Supplementation on Acid-Base Balance and Prolonged High-Intensity Interval Cycling Performance.Journal of functional morphology and kinesiology · 2024Article
- Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Synergic effect of exogenous lactate and caffeine on fat oxidation and hepatic glycogen concentration in resting rats.Physical activity and nutrition · 2022Article
- Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.International journal of molecular sciences · 2022Article
- Tracing the lactate shuttle to the mitochondrial reticulum.Experimental & molecular medicine · 2022Review
- Lactate in contemporary biology: a phoenix risen.The Journal of physiology · 2022Article
- Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise.Nutrients · 2022Article
- The "Anaerobic Threshold" Concept Is Not Valid in Physiology and Medicine.Medicine and science in sports and exercise · 2021Article
- Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the Western World?Antioxidants (Basel, Switzerland) · 2021Review
- The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU.Journal of sport and health science · 2020Review
- The Precious Few Grams of Glucose During Exercise.International journal of molecular sciences · 2020Review
- Lactate as a fulcrum of metabolism.Redox biology · 2020Review
- Oral Lactate Administration Additively Enhances Endurance Training-Induced Increase in Cytochrome C Oxidase Activity in Mouse Soleus Muscle.Nutrients · 2020Article
- New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity.iScience · 2019Article
- Effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei of exercised rats.Journal of exercise nutrition & biochemistry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exogenous carbohydrate oxidation was assessed in 6 male Category 1 and 2 cyclists who consumed CytoMax (C) or a leading sports drink (G) before and during continuous exercise (CE). C contained lactate-polymer, fructose, glucose and glucose polymer, while G contained fructose and glucose. Peak power output and VO2 on a cycle ergometer were 408+/-13 W and 67.4+/-3.2 mlO2 x kg(-1) x min(-1). Subjects performed 3 bouts of CE with C, and 2 with G at 62% VO2peak for 90 min, followed by high intensity (HI) exercise (86% VO(2)peak) to volitional fatigue. Subjects consumed 250 ml fluid immediately before (-2 min) and every 15 min of cycling. Drinks at -2 and 45 min contained 100 mg of [U-(13)C]-lactate, -glucose or -fructose. Blood, pulmonary gas samples and 13CO2 excretion were taken prior to fluid ingestion and at 5,10,15,30,45,60,75, and 90 min of CE, at the end of HI, and 15 min of recovery. HI after CE was 25% longer with C than G (6.5+/-0.8 vs. 5.2+/-1.0 min, P<0.05). 13CO2 from the -2 min lactate tracer was significantly elevated above rest at 5 min of exercise, and peaked at 15 min. 13CO2 from the -2 min glucose tracer peaked at 45 min for C and G. 13CO2 increased rapidly from the 45 min lactate dose, and by 60 min of exercise was 33% greater than glucose in C or G, and 36% greater than fructose in G. 13CO2 production following tracer fructose ingestion was greater than glucose in the first 45 minutes in C and G. Cumulative recoveries of tracer during exercise were: 92%+/-5.3% for lactate in C and 25+/-4.0% for glucose in C or G. Recoveries for fructose in C and G were 75+/-5.9% and 26+/-6.6%, respectively. Lactate was used more rapidly and to a greater extent than fructose or glucose. CytoMax significantly enhanced HI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.