Evidence map›Paper›PMID 17895895›Full record

Trial reportBritish journal of cancer2007

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study.

P Osterlund, T Ruotsalainen, R Korpela, M Saxelin, A Ollus, P Valta, M Kouri, I Elomaa, H Joensuu

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00591474 (The Influence of Probiotics on Vancomycin-Resistant Enterococcus), which is not on this map. Cited by 185 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 17 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00591474 naterminatednot on this map

The Influence of Probiotics on Vancomycin-Resistant Enterococcus

TypeinterventionalSponsorOregon Health and Science UniversityRan2007 to 2010Enrolled8ConditionsGI Colonization of Vancomycin-resistant EnterococcusArmsprobiotics, yogurt
3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 17 syntheses or guidelines pooled it, 392 citations in OpenAlex.

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  12. Microbiome-gut-brain axis in cancer treatment-related psychoneurological toxicities and symptoms: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  15. Systematic review of agents for the management of gastrointestinal mucositis in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

P OsterlundDepartment of Oncology, Helsinki University Central Hospital, PO Box 180, 00029 HUS Helsinki, Finland. pia.osterlund@hus.fi
T Ruotsalainen
R Korpela
M Saxelin
A Ollus
P Valta
M Kouri
I Elomaa
H Joensuu
Helsinki University Hospital · FIJorvi Hospital · FIUniversity of Helsinki · FIValio (Finland) · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Fluorouracil (5-FU)-based chemotherapy is frequently associated with diarrhoea. We compared two 5-FU-based regimens and the effect of Lactobacillus and fibre supplementation on treatment tolerability. Patients diagnosed with colorectal cancer (n=150) were randomly allocated to receive monthly 5-FU and leucovorin bolus injections (the Mayo regimen) or a bimonthly 5-FU bolus plus continuous infusion (the simplified de Gramont regimen) for 24 weeks as postoperative adjuvant therapy. On the basis of random allocation, the study participants did or did not receive Lactobacillus rhamnosus GG supplementation (1-2 x 10(10) per day) and fibre (11 g guar gum per day) during chemotherapy. Patients who received Lactobacillus had less grade 3 or 4 diarrhoea (22 vs 37%, P=0.027), reported less abdominal discomfort, needed less hospital care and had fewer chemotherapy dose reductions due to bowel toxicity. No Lactobacillus-related toxicity was detected. Guar gum supplementation had no influence on chemotherapy tolerability. The simplified de Gramont regimen was associated with fewer grade 3 or 4 adverse effects than the Mayo regimen (45 vs 89%), and with less diarrhoea. We conclude that Lactobacillus GG supplementation is well tolerated and may reduce the frequency of severe diarrhoea and abdominal discomfort related to 5-FU-based chemotherapy.

Indexed as

Lacticaseibacillus rhamnosusAdenocarcinomaAdultAgedAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsDiarrheaFemaleFluorouracilGalactansHumansLeucovorinMaleMannansMiddle AgedNeoplasm StagingFluorouracilGalactansguar gumLeucovorinMannansPlant Gums

Identifiers

PMID17895895
PMCPMC2360429
OpenAlexW2128822027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.