SynthesisBritish journal of cancer2007
National study of colorectal cancer genetics.
Synthesis in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 11 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.Nature genetics · 2017Pooled it
- Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.Molecular carcinogenesis · 2017Pooled it
- A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.Scientific reports · 2016Pooled it
- Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.Nature communications · 2016Pooled it
- Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.Human molecular genetics · 2016Pooled it
- Genome-wide association study identifies multiple susceptibility loci for glioma.Nature communications · 2015Pooled it
- Pooled it
- Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.Human molecular genetics · 2014Pooled it
- A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.Nature genetics · 2014Pooled it
- Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.Nature communications · 2013Pooled it
- Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.Nature genetics · 2008Pooled it
- Linkage analysis in familial non-Lynch syndrome colorectal cancer families from Sweden.PloS one · 2013Trial
- Association analyses identify 31 new risk loci for colorectal cancer susceptibility.Nature communications · 2019Article
- Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.Neuro-oncology · 2018Article
- A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.Leukemia · 2017Article
- Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.Nature communications · 2017Article
- Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes.Familial cancer · 2016Article
- Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.Nature communications · 2016Article
- CanVar: A resource for sharing germline variation in cancer patients.F1000Research · 2016Article
- Identification of four new susceptibility loci for testicular germ cell tumour.Nature communications · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Approximately, a third of all colorectal cancer (CRC) is due to inherited susceptibility. However, high-risk mutations in APC, the mismatch repair (MMR) genes, MUTYH/MYH, SMAD4, ALK3 and STK11/LKB1 are rare and account for <5% of cases. Much of the remaining variation in genetic risk is likely to be explained by combinations of more common gene variants that modestly increase risk. Reliable identification of such 'low penetrance' alleles would provide insight into the aetiology of CRC and might highlight potential therapeutic and preventative interventions. In 2003, the National Study of Colorectal Cancer Genetics (NSCCG) was established with the aim of collecting DNA and clinicopathological data from 20,000 CRC cases and a series of spouse/partner controls, thereby creating a unique resource for identifying low-penetrance CRC susceptibility alleles. The National Cancer Research Network (NCRN) adopted NSCCG onto its portfolio of trials and 148 centres in the United Kingdom (UK) are now actively participating. Over 8,700 cases and 2,185 controls have so far been entered into NSCCG. Our experience in developing NSCCG serves to illustrate how world-class DNA databases for genetic analyses can be rapidly developed in the United Kingdom.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.