ArticleGenome research2007
The rise and spread of a new pathogen: seroresistant Moraxella catarrhalis.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system.Nature communications · 2025Article
- A global perspective on the genomics ofMicrobial genomics · 2025Article
- Understanding the population structure ofbioRxiv : the preprint server for biology · 2025Article
- Informed interpretation of metagenomic data by StrainPhlAn enables strain retention analyses of the upper airway microbiome.mSystems · 2023Article
- The characterization ofMicrobial genomics · 2022Article
- The EnteroBase user's guide, with case studies onGenome research · 2020Article
- Moraxella catarrhalis phase-variable loci show differences in expression during conditions relevant to disease.PloS one · 2020Article
- Moraxella catarrhalis NucM is an entry nuclease involved in extracellular DNA and RNA degradation, cell competence and biofilm scaffolding.Scientific reports · 2019Article
- Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.Genome biology and evolution · 2018Article
- Virulence factors of Moraxella catarrhalis outer membrane vesicles are major targets for cross-reactive antibodies and have adapted during evolution.Scientific reports · 2018Article
- Use of next generation sequence to investigate potential novel macrolide resistance mechanisms in a population of Moraxella catarrhalis isolates.Scientific reports · 2016Article
- How old are bacterial pathogens?Proceedings. Biological sciences · 2016Review
- The Impact of Selection, Gene Conversion, and Biased Sampling on the Assessment of Microbial Demography.Molecular biology and evolution · 2016Article
- Draft Genome Sequence of Moraxella catarrhalis Type Strain CCUG 353T.Genome announcements · 2016Article
- Comparative Genomic Analyses of the Moraxella catarrhalis Serosensitive and Seroresistant Lineages Demonstrate Their Independent Evolution.Genome biology and evolution · 2016Article
- Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications.BMC genomics · 2016Article
- Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity.BMC genomics · 2015Article
- Differential gene expression of Moraxella catarrhalis upon exposure to human serum.Genomics data · 2014Article
- Role of the oligopeptide permease ABC Transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract.Infection and immunity · 2014Article
- Population expansions shared among coexisting bacterial lineages are revealed by genetic evidence.PeerJ · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nosocomial human pathogen Moraxella catarrhalis is one the most important agents of human respiratory tract infections. This species is composed of two distinct lineages, one of only moderate virulence, the so-called serosensitive subpopulation, and a second, the seroresistant one, which is enriched among strains that harbor two major virulence traits: complement resistance and adherence to epithelial cells. Using a suite of population genetics tools, we show that the seroresistant lineage is also characterized by higher homologous recombination and mutation rates at housekeeping genes relative to its less pathogenic counterpart. Thus, sex and virulence have evolved in tandem in M. catarrhalis. Moreover, phylogenetic and Bayesian analyses that take into account recombination between the two clades show that the ancestral group was avirulent, is possibly 70 million years old, and must have infected mammals prior to the evolution of humans, which occurred later. The younger seroresistant isolates went through an important population expansion some 5 million years ago, coincident with the hominid expansion. This rise and spread was possibly coupled with a host shift and the acquisition of virulence genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.