ArticleGenome research2007
Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Churros: a Docker-based pipeline for large-scale epigenomic analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- The complete sequence of a human genome.Science (New York, N.Y.) · 2022Article
- Short arms of human acrocentric chromosomes and the completion of the human genome sequence.Genome research · 2022Article
- Segmental duplications and their variation in a complete human genome.Science (New York, N.Y.) · 2022Article
- Expanding studies of chromosome structure and function in the era of T2T genomics.Human molecular genetics · 2021Review
- Using de novo assembly to identify structural variation of eight complex immune system gene regions.PLoS computational biology · 2021Article
- Prevalence and Phenotypic Impact of Robertsonian Translocations.Molecular syndromology · 2021Review
- Human NORs, comprising rDNA arrays and functionally conserved distal elements, are located within dynamic chromosomal regions.Genes & development · 2019Article
- Clusters of alpha satellite on human chromosome 21 are dispersed far onto the short arm and lack ancient layers.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Narrowing the localization of the region breakpoint in most frequent Robertsonian translocations.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Genomic characterization of large heterochromatic gaps in the human genome assembly.PLoS computational biology · 2014Article
- The shared genomic architecture of human nucleolar organizer regions.Genome research · 2013Article
- Using population admixture to help complete maps of the human genome.Nature genetics · 2013Article
- Human centromere genomics: now it's personal.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Evidence for bacterial origin of heat shock RNA-1.RNA (New York, N.Y.) · 2010Article
- Evolutionary dynamics of segmental duplications from human Y-chromosomal euchromatin/heterochromatin transition regions.Genome research · 2008Article
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Authors and funding
26 authors.
Funding
Abstract
The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.
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