ArticleGut2008
Helicobacter pylori infection and the risk of Barrett's oesophagus: a community-based study.
Article in Gut, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Helicobacter pylori infection is associated with reduced risk of Barrett's esophagus: a meta-analysis and systematic review.BMC gastroenterology · 2021Pooled it
- Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta-analysis and systematic review.Helicobacter · 2018Pooled it
- The association between Barrett's esophagus and Helicobacter pylori infection: a meta-analysis.Helicobacter · 2012Pooled it
- Risk factors for barrett's esophagus identified in a large-scale Japanese community cohort study.Scientific reports · 2026Article
- Review
- The microbiome in cancer.iMeta · 2025Review
- Article
- Infectious agents and progression from Barrett's oesophagus to oesophageal adenocarcinoma: a nested case-control study.British journal of cancer · 2025Article
- Cancer Risk in Barrett's Esophagus: A Clinical Review.International journal of molecular sciences · 2023Review
- Association of Barrett's esophagus withTherapeutic advances in chronic disease · 2022Article
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Narrative review of the role of gastroenterologist in the diagnosis, treatment and palliation in gastric and gastroesophageal cancer.Annals of translational medicine · 2020Review
- Prevalence and risk factors for Barrett's esophagus in Taiwan.World journal of gastroenterology · 2019Article
- Interactions between Helicobacter pylori and gastroesophageal reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2019Review
- IS THERE A RELATION BETWEEN HELYBACTER PYLORI AND INTESTINAL METAPLASIA IN SHORT COLUMN EPITELIZATION UP TO 10 MM IN THE DISTAL ESOPHAGUS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019Article
- A New Gastric Cancer Among Us.Journal of the National Cancer Institute · 2018Article
- A case of simultaneous esophageal squamous cell carcinoma and Barrett's adenocarcinoma.Clinical journal of gastroenterology · 2016Article
- Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia.World journal of gastroenterology · 2016Article
- Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses.Cell reports · 2016Article
- Central Obesity and H. pylori Infection Influence Risk of Barrett's Esophagus in an Asian Population.PloS one · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveGastric colonisation with the Helicobacter pylori bacterium is a proposed protective factor against oesophageal adenocarcinoma, but its point of action is unknown. Its associations with Barrett's oesophagus, a metaplastic change that is a probable early event in the carcinogenesis of oesophageal adenocarcinoma, were evaluated
methodsA case-control study was carried out in the Kaiser Permanente Northern California population, a large health services delivery organisation. Persons with a new Barrett's oesophagus diagnosis (cases) were matched to subjects with gastro-oesophageal reflux disease (GORD) without Barrett's oesophagus and to population controls. Subjects completed direct in-person interviews and antibody testing for H pylori and its CagA (cytotoxin-associated gene product A) protein.
resultsSerological data were available on 318 Barrett's oesophagus cases, 312 GORD patients and 299 population controls. Patients with Barrett's oesophagus were substantially less likely to have antibodies for H pylori (OR = 0.42, 95% CI 0.26 to 0.70) than population controls; this inverse association was stronger among those with lower body mass indexes (BMIs < 25, OR = 0.03, 95% CI 0.00 to 0.20) and those with CagA+ strains (OR = 0.08, 95% CI 0.02 to 0.35). The associations were diminished after adjustment for GORD symptoms. The H pylori status was not an independent risk factor for Barrett's oesophagus compared with the GORD controls.
conclusionsHelicobacter pylori infection and CagA+ status were inversely associated with a new diagnosis of Barrett's oesophagus. The findings are consistent with the hypothesis that H pylori colonisation protects against Barrett's oesophagus and that the association may be at least partially mediated through GORD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.