ArticleBMC genetics2007
A multi-marker test based on family data in genome-wide association study.
Article in BMC genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.Genes and immunity · 2014Article
- A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children.Genetic epidemiology · 2014Article
- Detecting rare variants in case-parents association studies.PloS one · 2013Article
- Pseudosibship methods in the case-parents design.Statistics in medicine · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundComplex diseases are believed to be the results of many genes and environmental factors. Hence, multi-marker methods that can use the information of markers from different genes are appropriate for mapping complex disease genes. There already have been several multi-marker methods proposed for case-control studies. In this article, we propose a multi-marker test called a Multi-marker Pedigree Disequilibrium Test (MPDT) to analyze family data from genome-wide association studies. If the parental phenotypes are available, we also propose a two-stage test in which a genomic screening test is used to select SNPs, and then the MPDT is used to test the association of the selected SNPs.
resultsWe use simulation studies to evaluate the performance of the MPDT and the two-stage approach. The results show that the MPDT constantly outperforms the single marker transmission/disequilibrium test (TDT) 1. Comparing the power of the two-stage approach with that of the one-stage approach, which approach is more powerful depends on the value of the prevalence; when the prevalence is no less than 10%, the two-stage approach may be more powerful than the one-stage approach. Otherwise, the one-stage approach is more powerful.
conclusionThe proposed MPDT, is more powerful than the single marker TDT. When the parental phenotypes are available and the prevalence is no less than 10%, the proposed two-stage approach is more powerful than the one-stage approach.
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