ArticleNeural development2007
HSPC300 and its role in neuronal connectivity.
Article in Neural development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.Experimental & molecular medicine · 2023Review
- Vav independently regulates synaptic growth and plasticity through distinct actin-based processes.The Journal of cell biology · 2022Article
- BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.Nature communications · 2019Article
- New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.Disease models & mechanisms · 2017Article
- Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Journal of cell science · 2016Article
- The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular Synapses.Cell reports · 2016Article
- Emerging evidence for functional peptides encoded by short open reading frames.Nature reviews. Genetics · 2014Review
- Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complex.PloS one · 2014Article
- CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome.Frontiers in cellular neuroscience · 2014Review
- C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.Science (New York, N.Y.) · 2013Article
- The Notch signalling system: recent insights into the complexity of a conserved pathway.Nature reviews. Genetics · 2012Review
- NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.The EMBO journal · 2011Article
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- Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein.BMC cell biology · 2009Article
- The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis.Developmental biology · 2008Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe WAVE/SCAR complex, consisting of CYFIP (PIR121 or Sra1), Kette (Nap1), Abi, SCAR (WAVE) and HSPC300, is known to regulate the actin nucleating Arp2/3 complex in a Rac1-dependent manner. While in vitro and in vivo studies have demonstrated that CYFIP, Kette, Abi and SCAR work as subunits of the complex, the role of the small protein HSPC300 remains unclear.
resultsIn the present study, we identify the HSPC300 gene and characterize its interaction with the WAVE/SCAR complex in the Drosophila animal model. On the basis of several lines of evidence, we demonstrate that HSPC300 is an indispensable component of the complex controlling axonal and neuromuscular junction (NMJ) growth. First, the Drosophila HSPC300 expression profile resembles that of other members of the WAVE/SCAR complex. Second, HSPC300 mutation, as well as mutations in the other complex subunits, results in identical axonal and NMJ growth defects. Third, like with other complex subunits, defects in NMJ architecture are rescued by presynaptic expression of the respective wild-type gene. Fourth, HSPC300 genetically interacts with another subunit of the WAVE/SCAR complex. Fifth, HSPC300 physically associates with CYFIP and SCAR.
conclusionPresent data provide the first evidence for HSPC300 playing a role in nervous system development and demonstrate in vivo that this small protein works in the context of the WAVE/SCAR complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.