ArticleBMC veterinary research2007
Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters.
Article in BMC veterinary research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 9 citations in OpenAlex.
- Sciatic Integrity Is Necessary for Fast and Efficient Scrapie Infection After Footpad Injection.International journal of molecular sciences · 2025Article
- Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential.Emerging infectious diseases · 2025Article
- Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes.International journal of experimental pathology · 2013Article
- Possible case of maternal transmission of feline spongiform encephalopathy in a captive cheetah.PloS one · 2009Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundThe exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional lymph node (Ln. popliteus) on the pathogenesis of scrapie was monitored in a hamster model of prion infection via the footpad.
methodsSurgical lymphadenectomy was carried out at different time points after infection, or prior to inoculation, in order to elucidate the impact of the lymph node on lethal neuroinvasion.
resultsThe Ln. popliteus did not show an influence on pathogenesis when a high dose of infectivity was administered. However, it was found to modulate the interval of time until the development of terminal scrapie in a subset of animals lymphadenectomized after low-dose infection. In additon, lymphadenectomy performed four weeks before inoculation prevented cerebral PrP(TSE) deposition and development of disease during the period of observation (314 days) in the majority of hamsters challenged with a very low dose of scrapie agent.
conclusionOur findings suggest the regional lymph node as a potentially facilitating or even essential factor for invasion of the brain after peripheral challenge with low doses of infectious scrapie agent. The invasive in vivo approach pursued in this study may be applied also to other animal species for further elucidating the involvement of lymphoid tissue in the pathogenesis of experimental and natural TSEs.
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