ReviewMolecular psychiatry2007
Stress-induced changes in primate prefrontal profiles of gene expression.
Review in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Housekeeping genes in prostate tumorigenesis.International journal of cancer · 2009Pooled it
- Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior.Molecular psychiatry · 2021Article
- Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio).Scientific reports · 2021Article
- Early Life Stress, Frontoamygdala Connectivity, and Biological Aging in Adolescence: A Longitudinal Investigation.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.Translational psychiatry · 2019Article
- Autonomic complexity and emotion (dys-)regulation in early childhood across high- and low-risk contexts.Development and psychopathology · 2019Article
- Evidence of Reduced Agmatine Concentrations in the Cerebral Cortex of Suicides.The international journal of neuropsychopharmacology · 2018Article
- Stress amplifies sex differences in primate prefrontal profiles of gene expression.Biology of sex differences · 2017Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction.Translational psychiatry · 2017Review
- Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder.Scientific reports · 2017Article
- Chronic social defeat reduces myelination in the mouse medial prefrontal cortex.Scientific reports · 2017Article
- Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems.Translational psychiatry · 2017Article
- Inflammatory markers and suicidal attempts in depressed patients: A review.International journal of immunopathology and pharmacology · 2016Review
- Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice.Neurobiology of learning and memory · 2016Article
- Neuro-Epigenetic Indications of Acute Stress Response in Humans: The Case of MicroRNA-29c.PloS one · 2016Article
- The molecular bases of the suicidal brain.Nature reviews. Neuroscience · 2014Review
- Glucocorticoid regulates parkin expression in mouse frontal cortex: implications in schizophrenia.Current neuropharmacology · 2014Article
- Suicide and the polyamine system.CNS & neurological disorders drug targets · 2013Review
- Social regulation of human gene expression: mechanisms and implications for public health.American journal of public health · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Stressful experiences that consistently increase cortisol levels appear to alter the expression of hundreds of genes in prefrontal limbic brain regions. Here, we investigate this hypothesis in monkeys exposed to intermittent social stress-induced episodes of hypercortisolism or a no-stress control condition. Prefrontal profiles of gene expression compiled from Affymetrix microarray data for monkeys randomized to the no-stress condition were consistent with microarray results published for healthy humans. In monkeys exposed to intermittent social stress, more genes than expected by chance appeared to be differentially expressed in ventromedial prefrontal cortex compared to monkeys not exposed to adult social stress. Most of these stress responsive candidate genes were modestly downregulated, including ubiquitin conjugation enzymes and ligases involved in synaptic plasticity, cell cycle progression and nuclear receptor signaling. Social stress did not affect gene expression beyond that expected by chance in dorsolateral prefrontal cortex or prefrontal white matter. Thirty four of 48 comparisons chosen for verification by quantitative real-time polymerase chain reaction (qPCR) were consistent with the microarray-predicted result. Furthermore, qPCR and microarray data were highly correlated. These results provide new insights on the regulation of gene expression in a prefrontal corticolimbic region involved in the pathophysiology of stress and major depression. Comparisons between these data from monkeys and those for ventromedial prefrontal cortex in humans with a history of major depression may help to distinguish the molecular signature of stress from other confounding factors in human postmortem brain research.
Indexed as
Identifiers
17893703What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.