Evidence map›Paper›PMID 17893386›Full record

ReviewAnnals of family medicine

Differences among international pharyngitis guidelines: not just academic.

Jan Matthys, Marc De Meyere, Mieke L van Driel, An De Sutter

Registry-linked trialOpen access · diamondAbstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04256694 (Rapid Antigen Test Results for Group A Streptococcus in Healthy Adults), which is not on this map. Cited by 57 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 13 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04256694 unknown statusnot on this map

Rapid Antigen Test Results for Group A Streptococcus in Healthy Adults

TypeobservationalSponsorKendall Healthcare Group, Ltd.Ran2020 to 2021Enrolled200ConditionsStrept ThroatArmsRapid Antigen Test for Group A Streptococcus
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 13 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Different antibiotic treatments for group A streptococcal pharyngitis.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Different antibiotic treatments for group A streptococcal pharyngitis.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
  5. Pooled it
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  7. Antibiotics for preventing recurrent sore throat.The Cochrane database of systematic reviews · 2015
    Pooled it
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  11. Pooled it
  12. Guideline
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  14. Trial
  15. Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jan MatthysDepartment of Family Medicine and Primary Health Care, Ghent University, Belgium. jan.matthys@ugent.be
Marc De Meyere
Mieke L van Driel
An De Sutter
Ghent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMany countries have national guidelines for the treatment of pharyngitis. We wanted to compare the recommendations and the reported evidence in national guidelines for the management of acute sore throat in adults.

methodsGuidelines were retrieved via MEDLINE and EMBASE and through a Web-based search for guideline development organizations. The content of the recommendations and the underlying evidence were analyzed with qualitative and bibliometric methods.

resultsWe included 4 North American and 6 European guidelines. Recommendations differ with regard to the use of a rapid antigen test and throat culture and with the indication for antibiotics. The North American, French, and Finnish guidelines consider diagnosis of group A streptococcus essential, and prevention of acute rheumatic fever remains an important reason to prescribe antibiotics. In 4 of the 6 European guidelines, acute sore throat is considered a self-limiting disease and antibiotics are not recommended. The evidence used to underpin these guidelines was different in North America and Europe. North American guidelines cited more North American references than did European guidelines (87.2% vs 48.0%; ods ratio, 4.6-11.9; P<.001).

conclusionAlthough the evidence for the management of acute sore throat is easily available, national guidelines are different with regard to the choice of evidence and the interpretation for clinical practice. Also a transparent and standardized guideline development method is lacking. These findings are important in the context of appropriate antibiotic use, the problem of growing antimicrobial resistance, and costs for the community.

Indexed as

Cross-Cultural ComparisonPractice Guidelines as TopicAdultAnti-Bacterial AgentsEuropeEvidence-Based MedicineHumansNorth AmericaPenicillinsPharyngitisStreptococcal InfectionsAnti-Bacterial AgentsPenicillins

Identifiers

PMID17893386
PMCPMC2000301
OpenAlexW2119925402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.