ArticleProtein science : a publication of the Protein Society2007
WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases.
Article in Protein science : a publication of the Protein Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid.Pharmaceutics · 2023Article
- An Assay to Determine NAD(P)H: Quinone Oxidoreductase Activity in Cell Extracts fromBio-protocol · 2021Article
- Effects of the Quinone Oxidoreductase WrbA onAntioxidants (Basel, Switzerland) · 2021Article
- Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans.Infection and immunity · 2021Article
- An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival.PLoS pathogens · 2021Article
- Unveiling Kiwifruit Metabolite and Protein Changes in the Course of Postharvest Cold Storage.Frontiers in plant science · 2019Article
- WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System.Journal of bacteriology · 2016Article
- Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.Journal of microbiology (Seoul, Korea) · 2016Review
- Quantitative proteomic analysis of the influence of lignin on biofuel production by Clostridium acetobutylicum ATCC 824.Biotechnology for biofuels · 2016Article
- Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.PLoS pathogens · 2015Article
- Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric Acid.PloS one · 2015Article
- Molecular dynamics comparison of E. coli WrbA apoprotein and holoprotein.Journal of molecular modeling · 2014Article
- Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress.Journal of microbiology (Seoul, Korea) · 2014Article
- Molecular tracing of the emergence, diversification, and transmission of S. aureus sequence type 8 in a New York community.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Biphasic kinetic behavior of E. coli WrbA, an FMN-dependent NAD(P)H:quinone oxidoreductase.PloS one · 2012Article
- KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity.Journal of bacteriology · 2011Article
- Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast.PloS one · 2011Article
- Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity.Biochemistry · 2009Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.