ArticleProtein science : a publication of the Protein Society2007
Forbidden penta-peptides.
Article in Protein science : a publication of the Protein Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cellular Activity of CQWW Nullomer-Derived Peptides.ACS omega · 2025Article
- kmerDB: A database encompassing the set of genomic and proteomic sequence information for each species.Computational and structural biotechnology journal · 2024Article
- A survey of k-mer methods and applications in bioinformatics.Computational and structural biotechnology journal · 2024Review
- The determinants of the rarity of nucleic and peptide short sequences in nature.NAR genomics and bioinformatics · 2024Article
- Article
- Exploring objective feature sets in constructing the evolution relationship of animal genome sequences.BMC genomics · 2023Article
- Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity.Microorganisms · 2023Article
- Quasi-prime peptides: identification of the shortest peptide sequences unique to a species.NAR genomics and bioinformatics · 2023Article
- Evolutionary selection against short nucleotide sequences in viruses and their related hosts.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Enhancing the Immune Response of a Nicotine Vaccine with Synthetic Small "Non-Natural" Peptides.Molecules (Basel, Switzerland) · 2020Article
- Global pentapeptide statistics are far away from expected distributions.Scientific reports · 2018Article
- Computational analysis of nascent peptides that induce ribosome stalling and their proteomic distribution inRNA (New York, N.Y.) · 2017Article
- Amino acid sequence repertoire of the bacterial proteome and the occurrence of untranslatable sequences.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A frequency-based linguistic approach to protein decoding and design: Simple concepts, diverse applications, and the SCS Package.Computational and structural biotechnology journal · 2013Review
- Predicting nucleosome binding motif set and analyzing their distributions around functional sites of human genes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Pentamers not found in the universal proteome can enhance antigen specific immune responses and adjuvant vaccines.PloS one · 2012Article
- Genomic DNA k-mer spectra: models and modalities.Genome biology · 2009Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
There are 3,200,000 amino acid sequences of length 5 (penta-peptides). Statistically, we expect to see a distribution of penta-peptides that is determined by the frequency of the participating amino acids. We show, however, that not only are there thousands of such penta-peptides that are absent from all known proteomes, but many of them are coded for multiple times in the non-coding genomic regions. This suggests a strong selection process that prevents these peptides from being expressed. We also show that the characteristics of these forbidden penta-peptides vary among different phylogenetic groups (e.g., eukaryotes, prokaryotes, and archaea). Our analysis provides the first steps toward understanding the "grammar" of the forbidden penta-peptides.
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