ArticleBMC evolutionary biology2007
Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.BMC biology · 2021Article
- LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.Communications biology · 2021Article
- Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents.Molecular biology and evolution · 2020Article
- Rescue ofGenes · 2019Article
- Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox.Oncotarget · 2017Article
- Mild reproductive impact of a Y chromosome deletion on a C57BL/6J substrain.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Large deletion on the Y-chromosome long arm (Yq) of C57BL/6JBomTac inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Increased progesterone production in cumulus-oocyte complexes of female mice sired by males with the Y-chromosome long arm deletion and its potential influence on fertilization efficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Article
- SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression.The FEBS journal · 2014Article
- Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging.Journal of cell science · 2013Article
- A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse.PLoS genetics · 2012Article
- A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.PloS one · 2011Article
- Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression.The Journal of biological chemistry · 2010Article
- Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage.Genome biology · 2010Article
- Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.Journal of cell science · 2009Article
- The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.PLoS biology · 2009Article
- The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.Biology of reproduction · 2009Article
- Live offspring from mice lacking the Y chromosome long arm gene complement.Biology of reproduction · 2009Article
- Two novel mouse genes mapped to chromosome Yp are expressed specifically in spermatids.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe male-specific region of the mouse Y chromosome long arm (MSYq) contains three known highly multi-copy X-Y homologous gene families, Ssty1/2, Sly and Asty. Deletions on MSYq lead to teratozoospermia and subfertility or infertility, with a sex ratio skew in the offspring of subfertile MSYqdel males
resultsWe report the highly unusual genomic structure of a novel MSYq locus, Orly, and a diverse set of spermatid-specific transcripts arising from copies of this locus. Orly is composed of partial copies of Ssty1, Asty and Sly arranged in sequence. The Ssty1- and Sly-derived segments are in antisense orientation relative to each other, leading to bi-directional transcription of Orly. Genome search and phylogenetic tree analysis is used to determine the order of events in mouse Yq evolution. We find that Orly is the most recent gene to arise on Yq, and that subsequently there was massive expansion in copy number of all Yq-linked genes.
conclusionOrly has an unprecedented chimeric structure, and generates both "forward" (Orly) and "reverse" (Orlyos) transcripts arising from the promoters at each end of the locus. The region of overlap of known Orly and Orlyos transcripts is homologous to Sly intron 2. We propose that Orly may be involved in an intragenomic conflict between mouse X and Y chromosomes, and that this process underlies the massive expansion in copy number of the genes on MSYq and their X homologues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.