ArticleImmunity & ageing : I & A2007
Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers.
Article in Immunity & ageing : I & A, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Appropriate and acceptable health assessments for people experiencing homelessness.BMC public health · 2022Pooled it
- Effect of pilates on the physical and mental health of drug-dependent individuals - a randomized controlled trial.BMC psychiatry · 2025Trial
- The association of methadone use with physical function and frailty among persons who inject drugs.Addiction (Abingdon, England) · 2026Article
- Characterizing midlife-onset alcohol dependence: Implications for etiology, prevention, and healthy aging.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Differences in heroin overdose deaths in Australia by age, 2020-2022: Disease and estimated survival times.Drug and alcohol dependence reports · 2024Article
- Ageing and older people who use illicit opioids, cocaine or methamphetamine: a scoping review and literature map.Addiction (Abingdon, England) · 2022Article
- Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing.Brain communications · 2022Article
- Forensic human image identification using medical indicators.Forensic sciences research · 2022Article
- Shortened leukocyte telomere length in young adults who use methamphetamine.Translational psychiatry · 2021Article
- Increased expression of plasma hsa-miR-181a in male patients with heroin addiction use disorder.Journal of clinical laboratory analysis · 2020Article
- The OATH Syndemic: opioids and other substances, aging, alcohol, tobacco, and HIV.Current opinion in HIV and AIDS · 2020Review
- Substance Use Among Older People Living With HIV: Challenges for Health Care Providers.Frontiers in public health · 2019Review
- [Early onset substance abuse disorders and addictive diseases in old age].Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Increased Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Male Heroin Addicts: A Prospective Controlled Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Article
- Article
- HIV-associated cellular senescence: A contributor to accelerated aging.Ageing research reviews · 2017Review
- Is biological aging accelerated in drug addiction?Current opinion in behavioral sciences · 2017Article
- X Chromosome Inactivation in Opioid Addicted Women.Basic and clinical neuroscience · 2015Article
- Prefrontal cortical dopamine from an evolutionary perspective.Neuroscience bulletin · 2015Review
- Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems.Experimental biology and medicine (Maywood, N.J.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug addiction is associated with significant disease and death, but its impact on the ageing process has not been considered. The recent demonstration that many of the items available in routine clinical pathology have applicability as biomarkers of the ageing process implies that routine clinical laboratory parameters would be useful as an initial investigation of this possibility.
methods12,093 clinical laboratory results 1995-2006 were reviewed. To make the age ranges of the medical and addicted groups comparable the age range was restricted to 15-45 years.
results739 drug addicted (DA) and 5834 general medical (GM) age matched blood samples were compared. Significant elevation of immune parameters was noted in the C-reactive protein, erythrocyte sedimentation rate, total lymphocyte count, serum globulins and the globulin:albumin ratio (P < 0.01). Alanine aminotranferase, creatinine, urea, and insulin like growth factor-1 were also significantly higher (P < 0.01) in the DA group. Albumin, body mass index and dihydroepiandrosterone sulphate were unchanged and cholesterol was lower (all P < 0.05).
conclusionThese data demonstrate for the first time that addiction is associated with an altered profile of common biomarkers of ageing raising the possibility that the ageing process may be altered in this group. Infective and immune processes may be centrally involved. They suggest that addiction forms an interesting model to further examine the contribution of immune suppression and hyperstimulation to the ageing process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.