ArticlePediatric cardiology2008
Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-beta thalassemia.
Article in Pediatric cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Extracellular vesicles modulate endothelial nitric oxide production in patients with β‑thalassaemia/HbE.Biomedical reports · 2025Article
- Vascular Aging and Damage in Patients with Iron Metabolism Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Diagnosis of Systemic Diseases Using Infrared Spectroscopy: Detection of Iron Overload in Plasma-Preliminary Study.Biological trace element research · 2021Article
- Blockade of angiotensin ATBritish journal of pharmacology · 2020Article
- Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Iron Overload Damages the Endothelial MitochondriaOxidative medicine and cellular longevity · 2019Article
- Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects.PloS one · 2018Article
- Depleted nitric oxide and prostaglandin EInternational journal of hematology · 2017Article
- HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics.Antioxidants & redox signaling · 2017Review
- Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells.Frontiers in physiology · 2017Article
- Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Antioxidant and free radical scavenging activity of iron chelators.Toxicology reports · 2015Article
- Curcumin protects against cadmium-induced vascular dysfunction, hypertension and tissue cadmium accumulation in mice.Nutrients · 2014Article
- Molecular mechanism of yisui shengxue granule, a complex chinese medicine, on thalassemia patients suffering from hemolysis and anemia of erythrocytes.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Altered vascular function, arterial stiffness, and antioxidant gene responses in pediatric thalassemia patients.Pediatric cardiology · 2012Article
- Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability.Hypertension research : official journal of the Japanese Society of Hypertension · 2012Article
- Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide.The Journal of biological chemistry · 2011Article
- Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Consumption of Syzygium gratum promotes the antioxidant defense system in mice.Plant foods for human nutrition (Dordrecht, Netherlands) · 2010Article
- Oxidative modification and poor protective activity of HDL on LDL oxidation in thalassemia.Lipids · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thalassemia major is characterized by anemia, iron overload, and oxidant damage to major organs, especially the cardiovascular system. Oxidative stress is ultimately involved in endothelial dysfunction, a condition which is evident in adults suffering from various cardiovascular diseases including thalassemia. We investigated endothelial function in pediatric patients with hemoglobin E-beta thalassemia (HbE-beta thalassemia), who have been exposed to excessive iron and oxidative stress for much shorter period than adults with thalassemia. We recruited 22 blood transfusion-dependent HbE-beta thalassemia patients aged 11.8 +/- 2.9 years and 20 healthy controls aged 12.1 +/- 1.7 years. Oxidant status was determined, and endothelial function was assessed by a forearm blood flow technique. Oxidative stress was increased in the thalassemic patients, as blood glutathione (GSH) and ratios of reduced GSH to GSH disulfide were markedly reduced, and superoxide anion released from blood cells was highly elevated. Oxidative stress response, assessed by gamma-glutamylcysteine ligase activity, was increased approximately twofold in thalassemia patients. Basal forearm blood flow was significantly increased in patients compared with controls (7.3 +/- 1.8 vs 6.0 +/- 1.8 ml/100 ml tissue/min, respectively), whereas forearm vasodilatory response to reactive hyperemia was depressed by 50% in patients compared with controls. Endothelial function is impaired in young thalassemia patients, and impaired endothelial function is associated with oxidant stress.
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