ArticleImmunogenetics2007
The zebrafish activating immune receptor Nitr9 signals via Dap12.
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Rapid Natural Killer Cell Gene Responses, Generated by TLR Ligand-Induced Trained Immunity, Provide Protection to Bacterial Infection inInternational journal of molecular sciences · 2025Article
- Placing human gene families into their evolutionary context.Human genomics · 2022Review
- Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish.Brain, behavior, and immunity · 2022Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system.Immunogenetics · 2021Article
- Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages.Cells · 2021Review
- Article
- Single-cell transcriptional analysis reveals ILC-like cells in zebrafish.Science immunology · 2018Article
- Spotted Gar and the Evolution of Innate Immune Receptors.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017Article
- Article
- The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes.Immunogenetics · 2016Article
- Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.Developmental and comparative immunology · 2014Review
- Development and characterization of anti-nitr9 antibodies.Advances in hematology · 2012Article
- A model 450 million years in the making: zebrafish and vertebrate immunity.Disease models & mechanisms · 2012Review
- The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities.Immunogenetics · 2011Review
- Developmental and tissue-specific expression of NITRs.Immunogenetics · 2010Article
- Recognition of additional roles for immunoglobulin domains in immune function.Seminars in immunology · 2010Review
- Article
- Article
- A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.Immunity · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Both inhibitory and activating forms of natural killer (NK) cell receptors are found in mammals. The activating receptors play a direct role in the recognition of virally infected or transformed cells and transduce activating signals into the cell by partnering with an adaptor protein, which contains a cytoplasmic activation motif. Activating NK receptors encoded by the mammalian leukocyte receptor complex (e.g., killer cell immunoglobulin-like receptors) and the natural killer complex (e.g., Ly49s) partner with the adaptor protein DAP12, whereas NK receptors encoded in the CD94/NKG2 complex partner with the adaptor protein DAP10. Novel immune-type receptors (NITRs) found in bony fish share several common features with immunoglobulin-type NK receptors. Nitr9 is a putative activating receptor in zebrafish that induces cytotoxicity within the context of human NK cells. One isoform of Nitr9, Nitr9L, is shown here to preferentially partner with a zebrafish ortholog of Dap12. Cross-linking the Nitr9L-Dap12 complex results in activation of the phosphytidylinositol 3-kinase-->AKT-->extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.