ArticleOncogene2008
Gadd45 beta is a pro-survival factor associated with stress-resistant tumors.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases.Frontiers in immunology · 2025Review
- Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape.Frontiers in immunology · 2021Article
- GADD45B Facilitates Metastasis of Ovarian Cancer Through Epithelial-Mesenchymal Transition.OncoTargets and therapy · 2021Article
- GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy.Frontiers in endocrinology · 2020Article
- Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death.International neurourology journal · 2019Article
- Identification of Differentially Expressed Non-coding RNA in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs Responded to PRRSV.Scientific reports · 2018Article
- Loss of Gadd45b accelerates BCR-ABL-driven CML.Oncotarget · 2018Article
- Methylation mediated Gadd45β enhanced the chemosensitivity of hepatocellular carcinoma by inhibiting the stemness of liver cancer cells.Cell & bioscience · 2017Article
- Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.Brain research · 2016Article
- Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke.International journal of biological sciences · 2015Article
- Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.The Journal of experimental medicine · 2013Article
- Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.Respiratory research · 2013Article
- Identification of a novel endoplasmic reticulum stress response element regulated by XBP1.The Journal of biological chemistry · 2013Article
- Inherited genetic variation and overall survival following follicular lymphoma.American journal of hematology · 2012Article
- GADD45 proteins: central players in tumorigenesis.Current molecular medicine · 2012Review
- Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells.PloS one · 2011Article
- Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor.The Journal of biological chemistry · 2010Article
- Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach.Omics : a journal of integrative biology · 2010Article
- Rapid and dynamic alterations of gene expression profiles of adult porcine bone marrow-derived stem cell in response to hypoxia.Stem cell research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumors that acquire resistance against death stimuli constitute a severe problem in the context of cancer therapy. To determine genetic alterations that favor the development of stress-resistant tumors in vivo, we took advantage of polyclonal tumors generated after retroviral infection of newborn Elambda-MYC mice, in which the retroviral integration acts as a mutagen to enhance tumor progression. Tumor cells were cultivated ex vivo and exposed to gamma-irradiation prior to their transplantation into syngenic recipients, thereby providing a strong selective pressure for pro-survival mutations. Secondary tumors developing from stress-resistant tumor stem cells were analysed for retroviral integration sites to reveal candidate genes whose dysregulation confer survival. In addition to the gene encoding the antiapoptotic Bcl-x(L) protein, we identified the gadd45b locus to be a novel common integration site in these tumors, leading to enhanced expression. In accord with a thus far undocumented role of Gadd45beta in tumorigenesis, we showed that NIH3T3 cells overexpressing Gadd45beta form tumors in NOD/SCID mice. Interestingly and differently to other known 'classical' antiapoptotic factors, high Gadd45beta levels did not protect against MYC-, UV- or gamma-irradiation-induced apoptosis, but conferred a strong and specific survival advantage to serum withdrawal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.