ArticleJournal of dental research2007
Defining subphenotypes for oral clefts based on dental development.
Article in Journal of dental research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis.JDR clinical and translational research · 2021Pooled it
- Trial
- Sex-Dependent Prevalence of Sagittal Skeletal, Dental Malocclusions in Romanian Orthodontic Patients: An Observational Study.Journal of clinical medicine · 2026Article
- Hypodontia as an extended phenotype in families with nonsyndromic oral clefts: findings from a 39-family clinical cohort.Journal of applied oral science : revista FOB · 2026Observational
- Cleft lip Sidedness and the Association with Additional Congenital Malformations.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- Sidedness in Unilateral Orofacial Clefts: A Systematic Scoping Review.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- Injectable Resin Technique as a Restorative Alternative in a Cleft Lip and Palate Patient: A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- A Comprehensive Genetic Analysis of Slovenian Families with Multiple Cases of Orofacial Clefts Reveals Novel Variants in the GenesInternational journal of molecular sciences · 2023Article
- Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts.Clinics (Sao Paulo, Brazil) · 2023Article
- Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis.Dentistry journal · 2022Review
- Pulp enlargement in individuals born with cleft lip and palate pulp, a radiographic study from the cleft lip and palate service of paraiba, Brazil'.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Prevalence of Dental Anomalies in the Patient with Cleft Lip and Palate Visiting a Tertiary Care Hospital.JNMA; journal of the Nepal Medical Association · 2020Article
- Article
- Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study.The Journal of international medical research · 2019Article
- Nonsyndromic cleft lip and/or palate: A multicenter study of the dental anomalies involved.Journal of clinical and experimental dentistry · 2018Article
- Tooth agenesis code (TAC) in complete unilateral and bilateral cleft lip and palate patients.Odontology · 2018Article
- Review
- Third molar agenesis as a potential marker for craniofacial deformities.Archives of oral biology · 2018Article
- Cleft palate with/without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region.Clinical oral investigations · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used dental development to subphenotype clefts with the goal of identifying cleft subgroups that could have specific genetic contributions. We examined 1000 individuals, 500 with clefts and 500 without. We used several clinical features, such as cleft completeness or incompleteness, laterality, and the presence of dental anomalies to assess each individual's cleft status. We performed chi-square and Fisher's exact tests to compare the frequencies of observed anomalies between individuals with and individuals without clefts, and among individuals with different cleft subphenotypes. Agenesis of the lateral incisor on the non-cleft side was the most remarkable observation, and may suggest that such cases could be considered incomplete forms of bilateral clefts of the lip.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.