ArticleBiophysical journal2008
High-resolution cell surface dynamics of germinating Aspergillus fumigatus conidia.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis.PLoS computational biology · 2021Article
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- Establishment of a New PNA-FISH Method forMicroorganisms · 2020Article
- Macrophage activation on "phagocytic synapse" arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit.Science advances · 2020Article
- Article
- Genome sequence and spore germination-associated transcriptome analysis of Corynespora cassiicola from cucumber.BMC microbiology · 2020Article
- Simultaneous Nanoscale Imaging of Chemical and Architectural Heterogeneity on Yeast Cell Wall Particles.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- EphA2-Dependent Internalization ofFrontiers in microbiology · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used real-time atomic force microscopy with a temperature-controlled stage (37 degrees C) to probe the structural and physicochemical dynamics of single Aspergillus fumigatus conidia during germination. Nanoscale topographic images of dormant spores revealed the presence of a layer of rodlets made of hydrophobins, in agreement with earlier electron microscopy observations. Within the 3-h germination period, progressive disruption of the rodlet layer was observed, revealing hydrophilic inner cell wall structures. Using adhesion force mapping with hydrophobic tips, these ultrastructural changes were shown to correlate with major differences in cell surface hydrophobicity. That is, the rodlet surface was uniformly hydrophobic due to the presence of hydrophobins, whereas the cell wall material appearing upon germination was purely hydrophilic. This study illustrates the potential of real-time atomic force microscopy imaging and force spectroscopy for tracking cell-surface dynamics.
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