ArticleThe Plant cell2007
A cluster of disease resistance genes in Arabidopsis is coordinately regulated by transcriptional activation and RNA silencing.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- A Meta-Analysis Reveals Opposite Effects of Biotic and Abiotic Stresses on Transcript Levels of Arabidopsis Intracellular Immune Receptor Genes.Frontiers in plant science · 2021Pooled it
- Role of the Genetic Background in Resistance to Plant Viruses.International journal of molecular sciences · 2018Pooled it
- Dual regulation of the receptor-like kinase BIR1 involves site-directed transcript cleavage and 5'-leader-mediated translational control.PLoS pathogens · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis.Nature communications · 2025Article
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- Chromosome-level genome assembly and annotation of Ulmus minor reveal dynamic intrageneric clusters of resistance genes.The plant genome · 2025Article
- Extrachromosomal circular DNA and structural variants highlight genome instability in Arabidopsis epigenetic mutants.Nature communications · 2023Article
- Long-read direct RNA sequencing reveals epigenetic regulation of chimeric gene-transposon transcripts in Arabidopsis thaliana.Nature communications · 2023Article
- Impacts of DNA methylases and demethylases on the methylation and expression of Arabidopsis ethylene signal pathway genes.Functional & integrative genomics · 2023Article
- Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis.Nature plants · 2021Article
- Roles of small RNAs in crop disease resistance.Stress biology · 2021Review
- HopA1 Effector fromInternational journal of molecular sciences · 2021Article
- Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity.PLoS genetics · 2021Article
- The Critical Role of Small RNAs in Regulating Plant Innate Immunity.Biomolecules · 2021Review
- A Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana.Molecular biology and evolution · 2021Article
- Convergent Epigenetic Mechanisms Avoid Constitutive Expression of Immune Receptor Gene Subsets.Frontiers in plant science · 2021Article
- Turnip mosaic virus in oilseed rape activates networks of sRNA-mediated interactions between viral and host genomes.Communications biology · 2020Article
- Biotic stress triggered small RNA and RNAi defense response in plants.Molecular biology reports · 2020Review
- Pathogen-Associated Molecular Pattern-Triggered Immunity Involves Proteolytic Degradation of Core Nonsense-Mediated mRNA Decay Factors During the Early Defense Response.The Plant cell · 2020Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RPP5 (for recognition of Peronospora parasitica 5) locus in the Arabidopsis thaliana Columbia strain contains a cluster of paralogous disease Resistance (R) genes that play important roles in innate immunity. Among the R genes in this locus, RPP4 confers resistance to two races of the fungal pathogen Hyaloperonospora parasitica, while activation of SNC1 (for suppressor of npr1-1, constitutive 1) results in the resistance to another race of H. parasitica and to pathovars of the bacterial pathogen Pseudomonas syringae through the accumulation of salicylic acid (SA). Here, we demonstrate that other Columbia RPP5 locus R genes can be induced by transgenic overexpression of SNC1, which itself is regulated by a positive amplification loop involving SA accumulation. We also show that small RNA species that can target RPP5 locus R genes are produced in wild-type plants and that these R genes can be cosuppressed in transgenic plants overexpressing SNC1. Steady state expression levels of SNC1 increase in some mutants (dcl4-4, ago1-36, and upf1-5) defective in RNA silencing as well as in transgenic plants expressing the P1/Helper Component-Protease viral suppressor of RNA silencing. However, steady state levels of small RNA species do not change in mutants that upregulate SNC1. These data indicate many Columbia RPP5 locus R genes can be coordinately regulated both positively and negatively and suggest that the RPP5 locus is poised to respond to pathogens that disturb RNA silencing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.