ArticleGenetics2007
New properties of Drosophila fab-7 insulator.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.Molecular and cellular biology · 2017Article
- Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.Genetics · 2017Article
- Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.PLoS genetics · 2016Article
- Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Genetics · 2016Article
- Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex.Molecular and cellular biology · 2015Article
- The boundary paradox in the Bithorax complex.Mechanisms of development · 2015Article
- Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture.Genes · 2015Review
- Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.Epigenetics · 2014Article
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Mechanisms and proteins involved in long-distance interactions.Frontiers in genetics · 2014Review
- Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function.PLoS genetics · 2013Article
- Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux.Frontiers in genetics · 2012Article
- Selective interactions of boundaries with upstream region of Abd-B promoter in Drosophila bithorax complex and role of dCTCF in this process.Nucleic acids research · 2011Article
- Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions.Genes & development · 2009Article
- Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements.Nucleic acids research · 2008Article
- Chromatin insulators: regulatory mechanisms and epigenetic inheritance.Molecular cell · 2008Review
- Enhancer-promoter communication is regulated by insulator pairing in a Drosophila model bigenic locus.Molecular and cellular biology · 2008Article
- Functional interaction between the Fab-7 and Fab-8 boundaries and the upstream promoter region in the Drosophila Abd-B gene.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the Abd-B 3' cis-regulatory region, which is subdivided into a series of iab domains, boundary elements have previously been detected, including the Fab-7 element providing for the autonomous functioning of the iab-6 and iab-7 cis-regulatory domains. Here, it has been shown that a single copy of the 860-bp Fab-7 insulator effectively blocks the yellow and white enhancers. The eye and testis enhancers can stimulate the white promoter across the pair of Fab-7, which is indicative of a functional interaction between the insulators. Unexpectedly, Fab-7 has proved to lose the enhancer-blocking activity when placed near the white promoter. It seems likely that Fab-7 strengthens the relatively weak white promoter, which leads to the efficient enhancer-promoter interaction and insulator bypass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.