ArticleProceedings of the National Academy of Sciences of the United States of America2007
Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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Who cites it
54 citing papers in PubMed, 119 citations in OpenAlex.
- Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions.European journal of histochemistry : EJH · 2014Trial
- Association of B3GNT3 Expression with Tumour Stage and Lymph Node Metastasis in Colon Adenocarcinoma.International journal of molecular sciences · 2026Article
- B3GNT7 regulates mucin glycosylation and protects against colitis and infection.bioRxiv : the preprint server for biology · 2026Article
- B3GNT2, GPR35, PSMG1 Gene Polymorphisms Are Related With Susceptibility and Severity of Ankylosing Spondylitis in Chinese Han Population.Molecular genetics & genomic medicine · 2025Article
- Metabolomics andCommunications biology · 2024Article
- Review
- Article
- Endoglycosidase assay using enzymatically synthesized fluorophore-labeled glycans as substrates to uncover enzyme substrate specificities.Communications biology · 2022Article
- Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.Journal of extracellular vesicles · 2022Article
- Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma.Cellular & molecular biology letters · 2022Article
- Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma.Advances in experimental medicine and biology · 2022Article
- Analysis of Tumor Glycosylation Characteristics and Implications for Immune Checkpoint Inhibitor's Efficacy for Breast Cancer.Frontiers in immunology · 2022Article
- A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells.Scientific reports · 2021Article
- Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins.Cell chemical biology · 2021Article
- The Role of Glycosylation in Inflammatory Diseases.Advances in experimental medicine and biology · 2021Article
- Core-Fucosylated Tetra-AntennaryInternational journal of molecular sciences · 2019Article
- An automated platform for the enzyme-mediated assembly of complex oligosaccharides.Nature chemistry · 2019Article
- Increases in Tumor N-Glycan Polylactosamines Associated with Advanced HER2-Positive and Triple-Negative Breast Cancer Tissues.Proteomics. Clinical applications · 2019Article
- Identification of Poly-N-Acetyllactosamine-Carrying Glycoproteins from HL-60 Human Promyelocytic Leukemia Cells Using a Site-Specific Glycome Analysis Method, Glyco-RIDGE.Journal of the American Society for Mass Spectrometry · 2018Article
- Glycans as Key Checkpoints of T Cell Activity and Function.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta1,3-N-acetylglucosaminyltransferase 2 (beta3GnT2) is a polylactosamine synthase that synthesizes a backbone structure of carbohydrate structures onto glycoproteins. Here we generated beta3GnT2-deficient (beta3GnT2(-/-)) mice and showed that polylactosamine on N-glycans was markedly reduced in their immunological tissues. In WT mice, polylactosamine was present on CD28 and CD19, both known immune costimulatory molecules. However, polylactosamine levels on these molecules were reduced in beta3GnT2(-/-) mice. beta3GnT2(-/-) T cells lacking polylactosamine were more sensitive to the induction of intracellular calcium flux on stimulation with anti-CD3epsilon/CD28 and proliferated more strongly than T cells from WT mice. beta3GnT2(-/-) B cells also showed hyperproliferation on BCR stimulation. Macrophages from beta3GnT2(-/-) mice had higher cell surface CD14 levels and enhanced responses to endotoxin. These results indicate that polylactosamine on N-glycans is a putative immune regulatory factor presumably suppressing excessive responses during immune reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.