ArticleJournal of bacteriology2007
Local and global regulators linking anaerobiosis to cupA fimbrial gene expression in Pseudomonas aeruginosa.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
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- Sensor histidine kinasesFrontiers in cellular and infection microbiology · 2023Article
- Genome evolution drives transcriptomic and phenotypic adaptation inMicrobial genomics · 2021Article
- Seawater salt-trapped Pseudomonas aeruginosa survives for years and gets primed for salinity tolerance.BMC microbiology · 2019Article
- Core regulon of the global anaerobic regulator Anr targets central metabolism functions in Pseudomonas species.Scientific reports · 2019Article
- Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN.Nucleic acids research · 2018Article
- Use of a Multiplex Transcript Method for Analysis of Pseudomonas aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung.Infection and immunity · 2016Article
- SiaA/D Interconnects c-di-GMP and RsmA Signaling to Coordinate Cellular Aggregation of Pseudomonas aeruginosa in Response to Environmental Conditions.Frontiers in microbiology · 2016Article
- σ Factor and Anti-σ Factor That Control Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa.Journal of bacteriology · 2015Article
- Links between Anr and Quorum Sensing in Pseudomonas aeruginosa Biofilms.Journal of bacteriology · 2015Article
- Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment.Pathogens (Basel, Switzerland) · 2014Article
- Article
- Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.Journal of bacteriology · 2013Article
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- The CgrA and CgrC proteins form a complex that positively regulates cupA fimbrial gene expression in Pseudomonas aeruginosa.Journal of bacteriology · 2011Article
- Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA.Infection and immunity · 2011Article
- Article
- Epigenetic control of virulence gene expression in Pseudomonas aeruginosa by a LysR-type transcription regulator.PLoS genetics · 2009Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The cupA gene cluster of Pseudomonas aeruginosa encodes components and assembly factors of a putative fimbrial structure that enable this opportunistic pathogen to form biofilms on abiotic surfaces. In P. aeruginosa the control of cupA gene expression is complex, with the H-NS-like MvaT protein functioning to repress phase-variable (on/off) expression of the operon. Here we identify four positive regulators of cupA gene expression, including three unusual regulators encoded by the cgrABC genes and Anr, a global regulator of anaerobic gene expression. We show that the cupA genes are expressed in a phase-variable manner under anaerobic conditions and that the cgr genes are essential for this expression. We show further that cgr gene expression is negatively controlled by MvaT and positively controlled by Anr and anaerobiosis. Expression of the cupA genes therefore appears to involve a regulatory cascade in which anaerobiosis, signaled through Anr, stimulates expression of the cgr genes, resulting in a concomitant increase in cupA gene expression. Our findings thus provide mechanistic insight into the regulation of cupA gene expression and identify anaerobiosis as an inducer of phase-variable cupA gene expression, raising the possibility that phase-variable expression of fimbrial genes important for biofilm formation may occur in P. aeruginosa persisting in the largely anaerobic environment of the cystic fibrosis host lung.
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