ArticleMolecular cell2007
A transcription antiterminator constructs a NusA-dependent shield to the emerging transcript.
Article in Molecular cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Article
- Rho-dependent transcription termination: mechanisms and roles in bacterial fitness and adaptation to environmental changes.RNA (New York, N.Y.) · 2025Review
- Utilizing RNA-seq Data to Infer Bacterial Transcription Termination Sites and Validate Predictions.Methods in molecular biology (Clifton, N.J.) · 2024Article
- In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Structural basis of AlpA-dependent transcription antitermination.Nucleic acids research · 2022Article
- Transcription complexes as RNA chaperones.Transcription · 2021Article
- Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria.Nature communications · 2021Article
- Basic mechanisms and kinetics of pause-interspersed transcript elongation.Nucleic acids research · 2021Review
- NusA directly interacts with antitermination factor Q from phage λ.Scientific reports · 2020Article
- Role of a hairpin-stabilized pause in theRNA biology · 2019Article
- Trigger loop dynamics can explain stimulation of intrinsic termination by bacterial RNA polymerase without terminator hairpin contact.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Transcription elongation.Transcription · 2017Review
- NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble.eLife · 2016Article
- A universal transcription pause sequence is an element of initiation factor σ70-dependent pausing.Nucleic acids research · 2016Article
- Transcription is regulated by NusA:NusG interaction.Nucleic acids research · 2016Article
- Nascent RNA length dictates opposing effects of NusA on antitermination.Nucleic acids research · 2016Article
- Gifsy-1 Prophage IsrK with Dual Function as Small and Messenger RNA Modulates Vital Bacterial Machineries.PLoS genetics · 2016Article
- A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.Trends in biochemical sciences · 2016Review
- Bacterial RNA polymerase can retain σ70 throughout transcription.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
The universal bacterial transcription elongation factor NusA mediates elongation activities of RNA polymerase. By itself, NusA induces transcription pausing and facilitates intrinsic termination, but NusA also is a cofactor of antiterminators that antagonize pausing and prevent termination. We show that NusA is required for lambda-related phage 82 antiterminator Q(82) to construct a stable complex in which RNA-based termination mechanisms have restricted access to the emerging transcript; this result suggests a locale for both Q(82) and NusA near the beta flap domain of RNA polymerase. Furthermore, as NusA is not required for the antipausing activity of Q(82) in vitro, we distinguish two distinct activities of antiterminators, namely antipausing and RNA occlusion, and discuss their roles in Q(82) function.
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