ArticleJournal of autoimmunity2007
Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors.
Article in Journal of autoimmunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles.Frontiers in toxicology · 2023Review
- Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.Frontiers in immunology · 2020Article
- Molecular Landscape of Anti-Drug Antibodies Reveals the Mechanism of the Immune Response Following Treatment With TNFα Antagonists.Frontiers in immunology · 2019Article
- Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.Gastroenterology · 2018Article
- Evolution, immunity and the emergence of brain superautoantigens.F1000Research · 2017Article
- Plasma cell alloantigen ENPP1 is expressed by a subset of human B cells with potential regulatory functions.Immunology and cell biology · 2016Article
- Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases.Critical reviews in immunology · 2016Review
- Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis.World journal of gastroenterology · 2015Review
- Checkpoints that control B cell development.The Journal of clinical investigation · 2015Review
- Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease.Journal of clinical immunology · 2014Review
- Article
- Protective Roles of Natural IgM Antibodies.Frontiers in immunology · 2012Article
- B cell subsets in atherosclerosis.Frontiers in immunology · 2012Article
- Accumulation of B1-like B cells in transgenic mice over-expressing catalytically inactive RAG1 in the periphery.Immunology · 2011Article
- The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease.Current opinion in immunology · 2011Review
- Checkpoints in lymphocyte development and autoimmune disease.Nature immunology · 2010Review
- B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice.Hepatology (Baltimore, Md.) · 2009Article
- Atherosclerosis and autoimmunity.Clinical reviews in allergy & immunology · 2009Review
- The chemical pathway to primary biliary cirrhosis.Clinical reviews in allergy & immunology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
B-1 B-cells constitute a distinctive population of cells that are enriched for self-reactive B cell receptors (BCRs). These BCRs are encoded by a restricted set of heavy and light chains, including heavy chains that lack nontemplated nucleotide additions at the V-D and D-J joining regions. One prototype natural autoantibody produced by B-1 B cells binds to a cryptic determinant exposed on senescent red blood cells that includes the phosphatidylcholine (PtC) moiety. The V(H)11Vkappa9 BCR, which accounts for a large fraction of the anti-PtC specificity, is underrepresented in other B-cell populations, including newly formed B cells in bone marrow, and the transitional B cells, follicular B cells, and marginal zone B cells in spleen. Previous work has shown that V(H)11 heavy chains pair ineffectively with surrogate light chain (SLC) and so do not promote development in bone marrow, but instead allow fetal liver maturation because of a fetal preference for weaker pre-BCR signaling. Such inefficient SLC pairing constitutes one constraint on the maturation of B cells containing V(H)11 rearrangements that biases their generation to fetal development. Here, we examine another possible bottleneck to the B1 cell repertoire: light chain pairing with V(H)11 heavy chain, finding very significant preferences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.