ReviewMolecular immunology2008
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.
Review in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Signaling interactions predicted by the Tritope model of the TCR.Immunologic research · 2017Review
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- On the logic of restrictive recognition of peptide by the T-cell antigen receptor.Immunologic research · 2011Article
- On the opposing views of the self-nonself discrimination by the immune system.Immunology and cell biology · 2009Article
- Why rethink the structure-function relationships regulating TCR behavior?Current trends in immunology · 2009Article
- What roles do regulatory T cells play in the control of the adaptive immune response?International immunology · 2008Review
- A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.European journal of immunology · 2008Article
- What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?Molecular immunology · 2008Article
- An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition.Immunologic research · 2008Review
- The discussion with Jacques Miller: illustrating the limitations of pure empiricism.Immunology and cell biologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Based on the Tritope Model of the TCR [Cohn, M., 2005c. The Tritope Model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol. Immunol. 42, 1419-1443], a set of functional and evolutionary problems surrounding restrictive recognition of antigen are discussed. These include the origin of allele-specific recognition, the selection pressures for polygeneism and polymorphism, the TCR signaling interactions, the centrality of effector T-helper (eTh)-dependence for activation, the role of haplotype exclusion, "nonclassical" MHC-elements, alloreactivity versus xenoreactivity, etc. Further, a set of observations believed to support the Standard Model are reinterpreted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.