ReviewBiochemical pharmacology2008
Genetics of nicotine dependence and pharmacotherapy.
Review in Biochemical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Pooled it
- Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Pooled it
- Meta-analysis of 15 genome-wide linkage scans of smoking behavior.Biological psychiatry · 2010Pooled it
- Light and intermittent cigarette smokers: a review (1989-2009).Psychopharmacology · 2009Pooled it
- Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.Human molecular genetics · 2008Trial
- Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains.Journal of psychopharmacology (Oxford, England) · 2024Article
- Identification of Pathogenic Missense Mutations in the CHRNA5 Gene: A Computational Approach.Cureus · 2023Article
- Article
- Genetic Associations with Smoking Relapse and Proportion of Follow-up in Smoking Relapse throughout Adulthood in Pre- and Postmenopausal Women.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Article
- Association of NRG3 and ERBB4 gene polymorphism with nicotine dependence in Turkish population.Molecular biology reports · 2021Article
- Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility.International journal of environmental research and public health · 2021Article
- Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy.Frontiers in public health · 2021Review
- Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Nicotine Effects on White Matter Microstructure in Young Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Rationing elective surgery for smokers and obese patients: responsibility or prognosis?BMC medical ethics · 2018Article
- Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies.Scientific reports · 2017Article
- Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.Molecular brain · 2015Article
- Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey.BMC public health · 2015Article
- Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nicotine dependence is substantially heritable. Several regions across the genome have been implicated in containing genes that confer liability to nicotine dependence and variation in individual genes has been associated with nicotine dependence. Smoking cessation measures are also heritable, and measured genetic variation is associated with nicotine dependence treatment efficacy. Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving. These challenges include refinement of the nicotine dependence phenotype, better understanding of the dynamic interplay between genes and environment in nicotine dependence etiology, application and development of molecular and statistical methodology that can adequately address vast amounts of data, and continuous translational cross-talk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.