Evidence map›Paper›PMID 17888856›Full record

Trial reportAmerican journal of preventive medicine2007

Nicotine replacement and behavioral therapy for smoking cessation in pregnancy.

Kathryn I Pollak, Cheryl A Oncken, Isaac M Lipkus, Pauline Lyna, Geeta K Swamy, Pamela K Pletsch, Bercedis L Peterson, R Phillips Heine, Rebecca J Namenek Brouwer, Laura Fish and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of preventive medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00224419 (Testing Pharmacological Therapies for Pregnant Smokers), which is not on this map. Cited by 58 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 17 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00224419 phase4terminatednot on this map

Testing Pharmacological Therapies for Pregnant Smokers

TypeinterventionalSponsorDuke UniversityRan2003Enrolled181ConditionsSmoking, PregnancyArmsMotivational interviewing for smoking cessation, Cognitive behaviors therapy, CBT + NRT
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 17 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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  6. Nicotine replacement therapy versus control for smoking cessation.The Cochrane database of systematic reviews · 2018
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  17. Interventions for promoting smoking cessation during pregnancy.The Cochrane database of systematic reviews · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kathryn I PollakCancer Prevention, Detection and Control Research Program, Comprehensive Cancer Center, Duke University Medical Center, 2424 Erwin Road, Durham, NC 27705, USA. kathryn.pollak@duke.edu
Cheryl A Oncken
Isaac M Lipkus
Pauline Lyna
Geeta K Swamy
Pamela K Pletsch
Bercedis L Peterson
R Phillips Heine
Rebecca J Namenek Brouwer
Laura Fish
Evan R Myers
Duke Medical Center · USDuke University Hospital · USUConn Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Testing Pharmacological Therapies for Pregnant SmokersR01CA089053 · NCI · DUKE UNIVERSITY · PI POLLAK, KATHRYN I. · 2002 to 2006
$3.1M
NCI NIH HHS R01 CA 089053NCI NIH HHS R01 CA089053
6 · The paper itself

Abstract

backgroundThis study examines whether adding nicotine replacement therapy (NRT) to cognitive-behavioral therapy (CBT) for pregnant smokers increases rates of smoking cessation.

methodsAn open-label randomized trial (Baby Steps, n=181) of CBT-only versus CBT+NRT (choice of patch, gum, or lozenge; 1:2 randomization) was used. Data were collected from 2003 through 2005; analyses were conducted in 2006 and 2007. Outcomes were biochemically validated self-reported smoking status at 7 weeks post-randomization, 38 weeks gestation, and 3 months postpartum.

resultsWomen in the CBT+NRT arm were almost three times more likely than women in the CBT-only arm to have biochemically validated cessation at both pregnancy time points (after 7 weeks: 24% vs 8%, p=0.02; at 38 weeks gestation: 18% vs 7%, p=0.04), but not at 3 months postpartum (20% vs 14%, p=0.55). Recruitment was suspended early by an Independent Data and Safety Monitoring Board when an interim analysis found a higher rate of negative birth outcomes in the CBT+NRT arm than in the CBT-only arm. In the final analysis, the difference between the arms in rate of negative birth outcomes was 0.09 (p=0.26), when adjusted for previous history of preterm birth.

conclusionsThe addition of NRT to CBT promoted smoking cessation in pregnant women. This effect did not persist postpartum. More data are needed to determine safety parameters and to confirm the efficacy of NRT use during pregnancy.

Indexed as

Behavior TherapyAdultFemaleHumansNicotineNicotinic AgonistsNorth CarolinaPregnancySmoking CessationTobacco Use DisorderNicotineNicotinic Agonists

Identifiers

PMID17888856
PMCPMC3602964
OpenAlexW2165116321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.