Evidence map›Paper›PMID 17888443›Full record

ReviewJournal of chromatography. A2007

Fast, comprehensive two-dimensional liquid chromatography.

Dwight R Stoll, Xiaoping Li, Xiaoli Wang, Peter W Carr, Sarah E G Porter, Sarah C Rutan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of chromatography. A, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Applications of chromatographic methods in metabolomics: A review.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Biological Applications for LC-MS-Based Proteomics.Advances in experimental medicine and biology · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Reversed-phase fused-core HPLC modeling of peptides.Journal of pharmaceutical analysis · 2013
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dwight R StollUniversity of Minnesota, Department of Chemistry, Smith and Kolthoff Halls, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
Xiaoping Li
Xiaoli Wang
Peter W Carr
Sarah E G Porter
Sarah C Rutan

Funding

SURFACE MODIFIED ZIRCONIA IN ANALYTICAL CHROMATOGRAPHYR01GM054585 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CARR, PETER W · 1996 to 2011
$3.0M
NIGMS NIH HHS GM54585NIGMS NIH HHS R01 GM054585
6 · The paper itself

Abstract

The absolute need to improve the separating power of liquid chromatography, especially for multi-constituent biological samples, is becoming increasingly evident. In response, over the past few years, there has been a great deal of interest in the development of two-dimensional liquid chromatography (2DLC). Just as 1DLC is preferred to 1DGC based on its compatibility with biological materials we believe that ultimately 2DLC will be preferred to the much more highly developed 2DGC for such samples. The huge advantage of 2D chromatographic techniques over 1D methods is inherent in the tremendous potential increase in peak capacity (resolving power). This is especially true of comprehensive 2D chromatography wherein it is possible, under ideal conditions, to obtain a total peak capacity equal to the product of the peak capacities of the first and second dimension separations. However, the very long timescale (typically several hours to tens of hours) of comprehensive 2DLC is clearly its chief drawback. Recent advances in the use of higher temperatures to speed up isocratic and gradient elution liquid chromatography have been used to decrease the time needed to do the second dimension LC separation of 2DLC to about 20s for a full gradient elution run. Thus, fast, high temperature LC is becoming a very promising technique. Peak capacities of over 2000 and rates of peak capacity production of nearly 1 peak/s have been achieved. In consequence, many real samples showing more than 200 peaks with signal to noise ratios of better than 10:1 have been run in total times of under 30 min. This report is not intended to be a comprehensive review of 2DLC, but is deliberately focused on the issues involved in doing fast 2DLC by means of elevating the column temperature; however, many issues of broader applicability will be discussed.

Indexed as

Chromatography, LiquidAlgorithmsChromatography, GasChromatography, High Pressure LiquidChromatography, Ion ExchangeImage Processing, Computer-Assisted

Identifiers

PMID17888443
PMCPMC3205947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.