ArticleDevelopmental biology2007
Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
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- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues.bioRxiv : the preprint server for biology · 2023Article
- An improved organ explant culture method reveals stem cell lineage dynamics in the adulteLife · 2022Article
- The Cross-Talk Between EGFR and E-Cadherin.Frontiers in cell and developmental biology · 2021Review
- EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis.Cell reports · 2020Article
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- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Temporal regulation of Dpp signaling output in the Drosophila wing.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
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- Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters.BMC genomics · 2012Article
- Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila.Developmental biology · 2012Article
- The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development.Molecules and cells · 2012Article
- Impact of interactions between normal and transformed epithelial cells and the relevance to cancer.Cellular and molecular life sciences : CMLS · 2012Review
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- Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection.BMC biology · 2010Article
- Morphometry and structure of natural random tilings.The European physical journal. E, Soft matter · 2010Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and subcellular localization of the cell adhesion molecule DE-cadherin/Shotgun (Shg) in the differentiating wing epithelium. High Ras activity in presumptive vein cells directs the apical localization of Shg containing adherens junctions, whereas low Ras activity in intervein cells allows Shg to relocalize basally. These alterations in Shg-mediated adhesion control cell shape changes that are essential for vein morphogenesis. While Decapentaplegic (Dpp) acts downstream of Ras to maintain vein cell identity in the pupal wing, our results indicate that Ras controls Shg localization via a Dpp-independent mechanism. Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology.
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