ReviewBiotechnology letters2008
Engineering eukaryotic protein factories.
Review in Biotechnology letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Sigma-1 Receptor Activation by Fluvoxamine Ameliorates ER Stress, Synaptic Dysfunction and Behavioral Deficits in a Ketamine Model of Schizophrenia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Enhancement of protein production in Aspergillus niger by engineering the antioxidant defense metabolism.Biotechnology for biofuels and bioproducts · 2024Article
- An outlook to sophisticated technologies and novel developments for metabolic regulation in theFrontiers in bioengineering and biotechnology · 2023Review
- Quantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell LineIranian biomedical journal · 2018Article
- Balanced trafficking between the ER and the Golgi apparatus increases protein secretion in yeast.AMB Express · 2018Article
- Diminishing Returns on Intragenic Repeat Number Expansion in the Production of Signaling Peptides.Molecular biology and evolution · 2017Article
- Moderate Expression ofApplied and environmental microbiology · 2017Article
- The impact of respiration and oxidative stress response on recombinant α-amylase production byMetabolic engineering communications · 2016Article
- The amyR-deletion strain of Aspergillus niger CICC2462 is a suitable host strain to express secreted protein with a low background.Microbial cell factories · 2016Article
- Selenocystamine improves protein accumulation in chloroplasts of eukaryotic green algae.AMB Express · 2015Article
- Molecular Characterization of Endoplasmic Reticulum Oxidoreductin 1 from Bombyx mori.International journal of molecular sciences · 2015Article
- Early transcriptional events linked to induction of diapause revealed by RNAseq in larvae of drosophilid fly, Chymomyza costata.BMC genomics · 2015Article
- An Efficient Genome-Wide Fusion Partner Screening System for Secretion of Recombinant Proteins in Yeast.Scientific reports · 2015Article
- The effect of the unfolded protein response on the production of recombinant proteins in plants.Plant cell reports · 2015Review
- Article
- Modulation of chaperone gene expression in mutagenized Saccharomyces cerevisiae strains developed for recombinant human albumin production results in increased production of multiple heterologous proteins.Applied and environmental microbiology · 2008Article
- Engineering of chaperone systems and of the unfolded protein response.Cytotechnology · 2008Article
- Production of biopharmaceutical proteins by yeast: advances through metabolic engineering.BioengineeredReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.