ArticlePlant physiology2007
Reduced expression of succinyl-coenzyme A ligase can be compensated for by up-regulation of the gamma-aminobutyrate shunt in illuminated tomato leaves.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 172 citations in OpenAlex.
- Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress.Plants (Basel, Switzerland) · 2026Review
- Evolutionary dynamics and transcriptional diversification of GAD gene family in plants: a pan-species perspective in silico analysis.BMC plant biology · 2025Article
- Cost-effective production ofBiology methods & protocols · 2025Article
- Gamma-aminobutyric acid interactions with phytohormones and its role in modulating abiotic and biotic stress in plants.Stress biology · 2024Review
- Role of Gamma-Aminobutyric Acid in Plant Defense Response.Metabolites · 2023Review
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- Comparative Analysis of VOCs from Winter Melon Pomace Fibers before and after Bleaching Treatment with HMolecules (Basel, Switzerland) · 2022Article
- Comparative study on the influence of silicon and selenium to mitigate arsenic induced stress by modulating TCA cycle, GABA, and polyamine synthesis in rice seedlings.Ecotoxicology (London, England) · 2022Article
- A multi-organ metabolic model of tomato predicts plant responses to nutritional and genetic perturbations.Plant physiology · 2022Article
- Genome-wide association of the metabolic shifts underpinning dark-induced senescence in Arabidopsis.The Plant cell · 2022Article
- Comparative genomic analysis of the tricarboxylic acid cycle members in four Solanaceae vegetable crops and expression pattern analysis in Solanum tuberosum.BMC genomics · 2021Article
- Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.Plant & cell physiology · 2021Article
- Phenotypic effects from the expression of a deregulated AtGAD1 transgene and GABA pathway suppression mutants in maize.PloS one · 2021Article
- Different Metabolic Roles for Alternative Oxidase in Leaves of Palustrine and Terrestrial Species.Frontiers in plant science · 2021Article
- Can Alternative Metabolic Pathways and Shunts Overcome Salinity Induced Inhibition of Central Carbon Metabolism in Crops?Frontiers in plant science · 2020Review
- Primary Metabolite Responses to Oxidative Stress in Early-Senescing and Paraquat ResistantFrontiers in plant science · 2020Article
- The Arabidopsis EPlant molecular biology · 2019Article
- Alternative Oxidase Isoforms Are Differentially Activated by Tricarboxylic Acid Cycle Intermediates.Plant physiology · 2018Article
- GABA Shunt in Durum Wheat.Frontiers in plant science · 2018Review
- Forward genetic screens identify a role for the mitochondrial HER2 in E-2-hexenal responsiveness.Plant molecular biology · 2017Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing experimental evidence suggests that the tricarboxylic acid cycle in plants is of greater importance in illuminated photosynthetic tissues than previously thought. In this study, transgenic tomato (Solanum lycopersicum) plants expressing a fragment of the beta-subunit of succinyl-coenzyme A ligase in either the antisense orientation or using the RNA interference approach, however, revealed little alteration in either photosynthesis or plant growth despite exhibiting dramatic reductions in activity. Moreover, the rate of respiration was only moderately affected in the transformants, suggesting that this enzyme does not catalyze a crucial step in mitochondrial respiration. However, metabolite and transcript profiling of these lines alongside enzyme and label redistribution experiments revealed that, whereas considerable activity of this enzyme appears to be dispensable, the reason for such a mild phenotype in extremely inhibited lines was an up-regulation of an alternative pathway for succinate production-that offered by the gamma-aminobutyric acid shunt. When taken together, these data highlight the importance both of succinate production for mitochondrial metabolism and the interplay between various routes of its production. The results are discussed in the context of current models of plant respiration in mitochondrial and cellular metabolism of the illuminated leaf.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.