ArticleThe American journal of pathology2007
Thy-1 is expressed in hepatic myofibroblasts and not oval cells in stem cell-mediated liver regeneration.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Exploring the Role of Thy-1 and Its Soluble Form Regarding Fibrosis Severity in Primary Biliary Cholangitis and Metabolic Dysfunction-Associated Fatty Liver Disease.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- "Small Hepatocytes" in the Liver.Cells · 2023Review
- CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1Stem cell research & therapy · 2023Article
- Article
- Portal fibroblasts marked by the surface antigen Thy1 contribute to fibrosis in mouse models of cholestatic liver injury.Hepatology communications · 2017Article
- Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.The Journal of clinical investigation · 2017Article
- Response of Hepatic Stellate Cells to TGFB1 Differs from the Response of Myofibroblasts. Decorin Protects against the Action of Growth Factor.Pathology oncology research : POR · 2017Article
- Negligible Oval Cell Proliferation Following Ischemia-Reperfusion Injury With and Without Partial Hepatectomy.Ochsner journal · 2017Article
- The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis.Differentiation; research in biological diversity · 2016Review
- Article
- Advances in hepatic stem/progenitor cell biology.EXCLI journal · 2015Review
- Identification and characterization of mesenchymal-epithelial progenitor-like cells in normal and injured rat liver.The American journal of pathology · 2015Article
- Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.Fibrogenesis & tissue repair · 2013Article
- Stem cells in liver regeneration and their potential clinical applications.Stem cell reviews and reports · 2013Review
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.Genes & development · 2013Article
- Isolation of Hepatic Progenitor Cells From Human Liver With Cirrhosis Secondary to Biliary Atresia Using EpCAM or Thy-1 Markers.Cell medicine · 2012Article
- CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells.Stem cells and development · 2011Article
- The role of stem cells in liver repair and fibrosis.The international journal of biochemistry & cell biology · 2011Review
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thy-1, a marker of hematopoietic stem cells, has been reported to be expressed by oval cells proliferating during stem cell-mediated regeneration in rat liver, suggesting a relationship between the two cell populations. Consequently, Thy-1 has become an accepted cell surface marker to sort hepatic oval cells. In the present study we used the well-characterized 2-acetylaminfluorene/partial hepatectomy model to induce transit-amplification of hepatic oval cells in the regenerating liver and characterized Thy-1 expression using Northern hybridization, quantitative reverse transcriptase-polymerase chain reaction analysis, immunofluorescence confocal microscopy, and immunoelectronmicroscopy. We found that Thy-1 expression was induced during transit-amplification of the oval cell population, but Thy-1 mRNA was not present in the alpha-fetoprotein-expressing oval cells. Thy-1 protein was consistently present outside the basement membrane surrounding the oval cells. It overlapped frequently with smooth muscle actin staining. A similar cellular localization of the Thy-1 protein was found on human liver specimens with ductular reactions obtained from patients with fulminant liver failure. Furthermore, Thy-1 was expressed by myofibroblasts in experimental liver fibrosis models without oval cell proliferation. We conclude that Thy-1 is not a marker of oval cells but is present on a subpopulation of myofibroblasts/stellate cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.