ArticleEndocrinology2008
Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice.The Journal of clinical investigation · 2025Article
- The Role of Progesterone in Elf5 Activation and Milk Component Synthesis for Cell-Cultured Milk Production in MAC-T Cells.Animals : an open access journal from MDPI · 2024Article
- Effect of Soybean Isoflavones on Proliferation and Related Gene Expression of Sow Mammary Gland Cells In Vitro.Animals : an open access journal from MDPI · 2022Article
- Review
- Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes.Nature communications · 2021Article
- Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells.ACS omega · 2021Article
- 17Journal of the Endocrine Society · 2018Article
- Hypothesis: Neuroendocrine Mechanisms (Hypothalamus-Growth Hormone-STAT5 Axis) Contribute to Sex Bias in Pulmonary Hypertension.Molecular medicine (Cambridge, Mass.) · 2015Article
- Article
- Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.Journal of mammary gland biology and neoplasia · 2015Review
- Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy.Journal of mammary gland biology and neoplasia · 2015Review
- A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells.Nucleic acids research · 2013Article
- Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium.Breast cancer research : BCR · 2013Article
- Progestin effects on cell proliferation pathways in the postmenopausal mammary gland.Breast cancer research : BCR · 2013Article
- Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Role of phosphorylation in progesterone receptor signaling and specificity.Molecular and cellular endocrinology · 2012Review
- A humanized pattern of aromatase expression is associated with mammary hyperplasia in mice.Endocrinology · 2012Article
- Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition.The Journal of nutrition · 2012Article
- Polymorphisms of STAT5A gene and their association with milk production traits in Holstein cows.Molecular biology reports · 2012Article
- Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.Breast cancer research : BCR · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Signal transducer and activator of transcription (Stat)5a is a well-established regulator of mammary gland development. Several pathways for activating Stat5a have been identified, but little is known about the mechanisms that regulate its expression in this tissue. In this report, we used immunofluorescent staining to examine Stat5a expression in mammary epithelial cells during normal development and in response to treatment with the ovarian hormones estrogen (E) and progesterone (P). Stat5a was present at very low levels in the prepubertal gland and was highly induced in a subset of luminal epithelial cells during puberty. The percentage of positive cells increased in adult virgin, pregnant, and lactating animals, dropped dramatically during involution, and then increased again after weaning. Ovariectomy ablated Stat5a expression in virgin animals, and treatment with both E and P was necessary to restore it. Double-labeling experiments in animals treated with E plus P for 3 d demonstrated that Stat5a was localized exclusively to cells containing both E and P receptors. Together, these results identify a novel role for E and P in inducing Stat5a expression in the virgin mammary gland and suggest that these hormones act at the cellular level through their cognate receptors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.