ArticleThe Journal of physiology2007
Postnatal developmental changes in activation profiles of the respiratory neuronal network in the rat ventral medulla.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Endomorphin-2 (Endo2) and substance P (SubP) co-application attenuates SubP-induced excitation and alters frequency plasticity in neonatal rat in vitro preparations.Respiratory physiology & neurobiology · 2025Article
- Review
- Neural bases for the genesis and COFrontiers in neuroscience · 2023Article
- Mu-opioid receptor-dependent transformation of respiratory motor pattern in neonatesFrontiers in physiology · 2022Article
- Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression.Frontiers in physiology · 2021Article
- Structural and functional connectivity from the dorsomedial hypothalamus to the ventral medulla as a chronological amplifier of sympathetic outflow.Scientific reports · 2020Article
- Time and dose-dependent impairment of neonatal respiratory motor activity after systemic inflammation.Respiratory physiology & neurobiology · 2020Article
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- Optogenetic analysis of respiratory neuronal networks in the ventral medulla of neonatal rats producing channelrhodopsin in Phox2b-positive cells.Pflugers Archiv : European journal of physiology · 2019Article
- Structural and functional identification of two distinct inspiratory neuronal populations at the level of the phrenic nucleus in the rat cervical spinal cord.Brain structure & function · 2019Article
- Article
- Article
- Role of parafacial nuclei in control of breathing in adult rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Standardization of size, shape and internal structure of spinal cord images: comparison of three transformation methods.PloS one · 2013Article
- Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dual oscillator model of the respiratory neuronal network generating quantal slowing of respiratory rhythm.Journal of computational neuroscience · 2011Article
- The locus coeruleus and central chemosensitivity.Respiratory physiology & neurobiology · 2010Review
- Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation.The Journal of physiology · 2009Article
- Opioids prolong and anoxia shortens delay between onset of preinspiratory (pFRG) and inspiratory (preBötC) network bursting in newborn rat brainstems.Pflugers Archiv : European journal of physiology · 2009Article
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3 authors.
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Abstract
Two putative respiratory rhythm generators (RRGs), the para-facial respiratory group (pFRG) and the pre-Bötzinger complex (preBötC), have been identified in the neonatal rodent brainstem. To elucidate their functional roles during the neonatal period, we evaluated developmental changes of these RRGs by optical imaging using a voltage-sensitive dye. Optical signals, recorded from the ventral medulla of brainstem-spinal cord preparations of neonatal (P0-P4) rats (n = 44), were analysed by a cross correlation method. With development during the first few postnatal days, the respiratory-related activity in the pFRG reduced and shifted from a preinspiratory (P0-P1) to an inspiratory (P2-P4) pattern, whereas preBötC activity remained unchanged. The mu-opioid agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) augmented preinspiratory activity in the pFRG, while the mu-opioid antagonist naloxone induced changes in spatiotemporal activation profiles that closely mimicked the developmental changes. These results are consistent with the recently proposed hypothesis by Janczewski and Feldman that the pFRG is activated to compensate for the depression of the preBötC by perinatal opiate surge. We conclude that significant reorganization of the respiratory neuronal network, characterized by a reduction of preinspiratory activity in the pFRG, occurs at P1-P2 in rats. The changes in spatiotemporal activation profiles of the pFRG neurones may reflect changes in the mode of coupling of the two respiratory rhythm generators.
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