ArticleRespiratory physiology & neurobiology2008
Calcitonin gene-related peptide affects synaptic and membrane properties of bronchial parasympathetic neurons.
Article in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Neurochemical alterations of intrinsic cardiac ganglionated nerve plexus caused by arterial hypertension developed during ageing in spontaneously hypertensive and Wistar Kyoto rats.Journal of anatomy · 2023Article
- Regulatory Peptides in Asthma.International journal of molecular sciences · 2021Review
- Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways.Neuroscience letters · 2021Review
- Neuroimmune Pathophysiology in Asthma.Frontiers in cell and developmental biology · 2021Review
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- CGRP inhibits neurons of the bed nucleus of the stria terminalis: implications for the regulation of fear and anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Characterization of the vagal motor neurons projecting to the Guinea pig airways and esophagus.Frontiers in neurology · 2010Article
- Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Calcitonin gene-related peptide (CGRP) is located with substance P in nerve varicosities in close apposition to principal neurons in airway parasympathetic ganglia. Substance P has multiple effects on airway parasympathetic neurons but the role of CGRP is unknown. Using intracellular current clamp recording of ganglionic neurons, stimulation of vagal afferent nerves in the presence of neurokinin receptor antagonists evoked hyperpolarization of the membrane potential which was blocked by the CGRP-1 receptor antagonist, CGRP(8-37). Exogenous application of alpha-CGRP (0.001-0.1 microM) hyperpolarized the membrane potential, which was either blocked or reversed to depolarization in the presence of CGRP(8-37), whereas higher concentrations of alpha-CGRP (1.0-10.0 microM) caused depolarization. Action potential accommodation in phasic-type neurons decreased in the presence of alpha-CGRP (0.1-10 microM). The co-localization of substance P- and CGRP-immunoreactivity was observed in nerve varicosities within ganglia; prolonged exposure to capsaicin in vitro depleted substance P and CGRP immunostaining in nerve varicosities. These results demonstrate that CGRP has multiple effects on the excitability of airway parasympathetic neurons and may alter their activity, ultimately affecting parasympathetic tone in the lower airways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.