ArticleNeuroscience2007
Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of the two-pore potassium channel subunit Task5 on neuronal function and signal processing in the auditory brainstem.Frontiers in cellular neuroscience · 2024Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modulation of Neuronal Potassium Channels During Auditory Processing.Frontiers in neuroscience · 2021Review
- Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation.Brain sciences · 2020Article
- Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.Nature communications · 2015Article
- The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3.Pflugers Archiv : European journal of physiology · 2015Review
- Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.The Journal of biological chemistry · 2014Article
- Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.Pflugers Archiv : European journal of physiology · 2014Article
- Age-related changes in the relationship between auditory brainstem responses and envelope-following responses.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss.F1000Research · 2014Article
- Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour.Molecular and cellular neurosciences · 2012Article
- A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats.Frontiers in neural circuits · 2012Article
- Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats.Molecular biology reports · 2011Article
- Tinnitus: Models and mechanisms.Hearing research · 2011Review
- Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.Neuroscience · 2011Article
- The two-pore domain K+ channel TASK-1 is closely associated with brain barriers and meninges.Journal of molecular histology · 2010Article
- Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Two-pore potassium channels can influence neuronal excitability by regulating background leakage of potassium ions and resting membrane potential. The present study used quantitative real time PCR and in situ hybridization to determine if the decreased activity from deafness would induce changes in two-pore potassium channel subunit expression in the rat inferior colliculus (IC). Ten subunits were assessed with quantitative real-time PCR at 3 days, 3 weeks and 3 months following bilateral cochlear ablation. TASK-1, TASK-5 and THIK-2 showed significant decreases in expression at all three times assessed. TASK-5, relatively specific to auditory neurons, had the greatest decrease. TWIK-1 was significantly decreased at 3 weeks and 3 months following deafness and TREK-2 was only significantly decreased at 3 days. TASK-3, TWIK-2, THIK-1, TRAAK and TREK-1 did not show any significant changes in gene expression. In situ hybridization was used to examine TASK-1, TASK-5, TWIK-1 and THIK-2 in the central nucleus, dorsal cortex and lateral (external) cortex of the IC in normal hearing animals and at 3 weeks following deafening. All four subunits showed expression in neurons throughout IC subdivisions in normal hearing rats, with TASK-5 having the greatest overall number of labeled neurons. There was no co-localization of subunit expression with glial fibrillary acidic protein immunostaining, indicating no expression in glia. Three weeks following deafening there was a significant decrease in the number of neurons expressing TASK-1 and THIK-2 in the IC, while TASK-5 had significant decreases in the central nucleus and dorsal cortex and TWIK-1 in the lateral and dorsal cortices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.