ArticleNeuroradiology2007
The influence of hemodynamic forces on biomarkers in the walls of elastase-induced aneurysms in rabbits.
Article in Neuroradiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Imaging of intracranial aneurysms in animals: a systematic review of modalities.Neurosurgical review · 2023Pooled it
- Association of wall shear stress with intracranial aneurysm rupture: systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Correlation between computational fluid dynamics-derived low wall shear stress and vessel wall enhancement on high-resolution MR vessel wall imaging in intracranial aneurysms.European radiology · 2026Article
- The Role of Gut and Oral Microbiota in the Formation and Rupture of Intracranial Aneurysms: A Literature Review.International journal of molecular sciences · 2023Review
- Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models.Stroke (Hoboken, N.J.) · 2023Article
- Computational Fluid Dynamics Analysis of Blood Flow Changes during the Growth of Saccular Abdominal Aortic Aneurysm.Annals of vascular diseases · 2022Article
- Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms.Frontiers in neurology · 2022Article
- CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.Scientific reports · 2021Article
- On the Potential Self-Amplification of Aneurysms Due to Tissue Degradation and Blood Flow Revealed From FSI Simulations.Frontiers in physiology · 2021Article
- The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2020Article
- Assessment of endothelialization of aneurysm wall over time in a rabbit model through CD31 scoring.Journal of neurointerventional surgery · 2018Article
- Computational Fluid Dynamics of Vascular Disease in Animal Models.Journal of biomechanical engineering · 2018Review
- Rabbit aneurysm models mimic histologic wall types identified in human intracranial aneurysms.Journal of neurointerventional surgery · 2018Article
- Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions.Frontiers in surgery · 2016Review
- RNA-Sequencing Analysis of Messenger RNA/MicroRNA in a Rabbit Aneurysm Model Identifies Pathways and Genes of Interest.AJNR. American journal of neuroradiology · 2015Article
- Diversity in the Strength and Structure of Unruptured Cerebral Aneurysms.Annals of biomedical engineering · 2015Article
- Adult vascular wall resident multipotent vascular stem cells, matrix metalloproteinases, and arterial aneurysms.Stem cells international · 2015Review
- Novel high-throughput in vitro model for identifying hemodynamic-induced inflammatory mediators of cerebral aneurysm formation.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension.Journal of neurointerventional surgery · 2014Article
- Inflammation and cerebral aneurysms.Translational stroke research · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionBiological and biophysical factors have been shown to play an important role in the initiation, progression, and rupture of intracranial aneurysms. The purpose of this study was to evaluate the association between hemodynamic forces and markers of vascular remodeling in elastase-induced saccular aneurysms in rabbits.
methodsElastase-induced aneurysms were created at the origin of the right common carotid artery in rabbits. Hemodynamic parameters were estimated using computational fluid dynamic simulations based on 3-D-reconstructed models of the vasculature. Expression of matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and markers of vascular remodeling were measured in different spatial regions within the aneurysms.
resultsAltered expression of biological markers relative to controls was correlated with the locations of subnormal time-averaged wall shear stress (WSS) but not with the magnitude of pressure. In the aneurysms, WSS was low and expression of biological markers was significantly altered in a time-dependent fashion. At 2 weeks, an upregulation of active-MMP-2, downregulation of TIMP-1 and TIMP-2, and intact endothelium were found in aneurysm cavities. However, by 12 weeks, endothelial cells were absent or scattered, and levels of pro- and active-MMP-2 were not different from those in control arteries, but pro-MMP-9 and both TIMPs were upregulated.
conclusionThese results reveal a strong, spatially localized correlation between diminished WSS and differential expression of biological markers of vascular remodeling in elastase-induced saccular aneurysms. The ability of the wall to function and maintain a healthy endothelium in a low shear environment appears to be significantly impaired by chronic exposure to low WSS.
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